Disabling defender as newer W10 versions are pushed out is getting harder.
I have successfully removed the windows defender service with no side effects so far.
Windows 10 Version 2004 build 19041.450
This eliminated defender service from the PC
Use an bootable offline registry editor of choice, I used a windows 7 64bit ERD disc to do it, not publicly available but can be found. It has a registry editor that ignores permissions.
Once booted into the registry editor navigate to
HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\services\WinDefend
delete the WinDefend key
I would export the key first, then if you want it back you can merge the saved key back into the registry and reboot.
You can disable sidebar security messages about defender:
Disable Security Messages on Windows 10
Tap on the Windows-key, type regedit.exe, and hit the Enter-key on the keyboard afterwards. Confirm the UAC prompt that appears.
Go to
HKEY_CURRENT_USER\SOFTWARE\Policies\Microsoft\Windows\Explorer
using the left sidebar menu. If Explorer does not exist, right-click on Windows Key and select New > Key, and name it Explorer. Right-click on Explorer, and select New > Dword (32-bit) Value.
Name it
DisableNotificationCenter.
Double-click the new entry afterwards, and set its value to 1.
Restart the PC