Using python 2.7 on windows 7 64 bit machine.

How to get a file close event:

 1. when file is opened in a new process of file opener (like notepad, wordpad which opens file everytime in new process of wordpad)
 2. when file is opened in a tab of file opener (like notepad++, which opens all files in new tab but there exist only a single process of notepad++ running)

So, how to get file close event in above cases? Is it possible to achieve above cases through  a common code? I am dealing with different file types