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    I could be wrong, but I don't think I even saw the .SUO file, until I closed VisualStudio.
    – Michael R
    Commented Feb 20, 2015 at 19:24
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    Just want to add - imperative that you close VS before deleting it. Deleting the file while VS is still open, then closing and reopening has NO effect. Must close first! Commented Nov 6, 2015 at 18:40
  • The above comment from @wizloc did it for me. To solve the problem for me, I had to close all open instances of VS (Visual Studio), before deleting the .suo file. When I deleted the .suo file with VS instances still open, closing and opening the solution did not solve the problem for me. Also, it's worth adding that I got this issue while trying to add a new project to my solution. Commented Sep 22, 2020 at 8:49