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I think it used to be aired in CN (Cartoon Network), it was a series about a pair of twins wearing a striped pyjamas. I think they lived in a groomy mansion or an old big house. I believe they had a sister but I could be wrong about that. A popular girl was the antagonist as she seemed to despise the twins. I believe they were kind of genius as they invented gadgets.

The twins looked somewhat like salad fingers, they weren't actually evil, just mischievous.

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    Was anything about this science fictional or fantastical? The gadgets bit seems like it might be but you probably want to flesh it out some more.
    – TheLethalCarrot ♦
    Commented Nov 16, 2022 at 15:34
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    That said twins in striped pyjamas... Bananas in Pyjamas?
    – TheLethalCarrot ♦
    Commented Nov 16, 2022 at 15:34
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    @TheLethalCarrot Nope, they were humans, they looked gloomy kinda like a mixture of Salad Fingers and Wednesday from Adam's Family Values. Without mentioning that Bananas in Pyjamas stripes are vertical, the ones I'm talking were horizontal
    – Mrc4t987
    Commented Nov 16, 2022 at 15:40
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    @TheLethalCarrot As an Aussie, I'm ashamed you beat me to that! :-D
    – Möoz
    Commented Nov 16, 2022 at 23:30

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Could this be "Edgar and Ellen"?

Seen below are twins (Not identical!) wearing striped clothing, holding some gadget looking devices.

Here's a summary from IMDB:

Based on a book series by Charles Ogden, lively animated series EDGAR & ELLEN revolves around the titular 12-year-old twins, whose primary mission in life is playing mischievous practical jokes (on each other as well as classmates and teachers) and putting the snooty residents of Nod's Limbs in their place. (Edgar and Ellen's adventures air as both an episodic cartoon series and longer specials.) Edgar and Ellen are voiced by Kathleen Barr and Jillian Michaels, respectively.

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