Glutamine and antioxidants: status of their use in critical illness

ARH van Zanten�- Current Opinion in Clinical Nutrition & Metabolic�…, 2015 - journals.lww.com
Current Opinion in Clinical Nutrition & Metabolic Care, 2015journals.lww.com
Given that the first dictum in medicine is to do no harm, we cannot be confident that immune-
modulating nutrient supplementation with glutamine and antioxidants is effective and well
tolerated for critically ill patients. Until more data are available, it is probably better not to
routinely administer glutamine and antioxidants in nonphysiological doses to mechanically
ventilated critically ill patients.
Summary
Given that the first dictum in medicine is to do no harm, we cannot be confident that immune-modulating nutrient supplementation with glutamine and antioxidants is effective and well tolerated for critically ill patients. Until more data are available, it is probably better not to routinely administer glutamine and antioxidants in nonphysiological doses to mechanically ventilated critically ill patients.
Lippincott Williams & Wilkins