Weight loss is recommended in all major guidelines for antihypertensive therapy. We
searched for randomized controlled trials investigating the effects of weight-reducing diets,
pharmacologic substances, and invasive interventions for weight reduction on patient-
relevant end points and blood pressure (BP) in patients with essential hypertension. No
information on the effects on patient-relevant end points was available. Patients assigned to
weight loss diets, orlistat, or sibutramine reduced their body weight more effectively than did�…