[HTML][HTML] Mediterranean dietary components are inversely associated with advanced colorectal polyps: A case-control study
N Fliss-Isakov, R Kariv, M Webb…�- World journal of�…, 2018 - ncbi.nlm.nih.gov
N Fliss-Isakov, R Kariv, M Webb, D Ivancovsky, D Margalit, S Zelber-Sagi
World journal of gastroenterology, 2018•ncbi.nlm.nih.govAIM To evaluate the association between the Mediterranean diet (MD) pattern and its
components, and advanced colorectal polyps (adenoma and serrated adenoma).
METHODS A case-control study among patients undergoing screening, diagnostic or
surveillance colonoscopies during 2010-2015 at the Tel-Aviv Medical Center,
Gastroenterology Department. Cases with advanced polyps were defined as: Advanced
adenoma [> 10 mm, with features of high grade dysplasia (HGD) or villous histology]�…
components, and advanced colorectal polyps (adenoma and serrated adenoma).
METHODS A case-control study among patients undergoing screening, diagnostic or
surveillance colonoscopies during 2010-2015 at the Tel-Aviv Medical Center,
Gastroenterology Department. Cases with advanced polyps were defined as: Advanced
adenoma [> 10 mm, with features of high grade dysplasia (HGD) or villous histology]�…
Abstract
AIM
To evaluate the association between the Mediterranean diet (MD) pattern and its components, and advanced colorectal polyps (adenoma and serrated adenoma).
METHODS
A case-control study among patients undergoing screening, diagnostic or surveillance colonoscopies during 2010-2015 at the Tel-Aviv Medical Center, Gastroenterology Department. Cases with advanced polyps were defined as: Advanced adenoma [> 10 mm, with features of high grade dysplasia (HGD) or villous histology], advanced serrated adenoma (> 10 mm or with dysplasia) or multiple (≥ 3) non-advanced adenomas or serrated adenomas. Cases of non-advanced adenomas were defined as adenomas< 10 mm, without features of HGD or villous histology. Controls were defined as those without polyps at the current colonoscopy and without a history of colorectal polyps. Data collection included: anthropometrics measured according to a standardized protocol, fasting blood tests performed at the same lab, medical history recorded by a structured interview and dietary intake evaluated by a 116-item food frequency questionnaire. Adherence to the MD components was evaluated according to intake above/below the sample median, for potentially beneficial/detrimental components respectively, as accepted.
RESULTS
We recruited 206 cases with advanced polyps, 192 cases with non-advanced adenoma and 385 controls. The number of adhered MD components was inversely associated with a diagnosis of advanced polyps in a dose-response manner (OR= 0.34, 95% CI: 0.17-0.65; OR= 0.22, 95% CI: 0.11-0.43; and OR= 0.18, 95% CI: 0.07-0.47 for 3-4, 5-7 and 8-10 components, respectively), but not with non-advanced adenomas (OR= 0.54, 95% CI: 0.25-1.13; OR= 0.48, 95% CI: 0.23-0.99; and OR= 0.43, 95% CI: 0.16-1.12 for 3-4, 5-7 and 8-10 components, respectively). Low intake of sugar-sweetened beverages and red meat, as well as high intake of fish, were inversely associated with advanced polyps (OR= 0.56, 95% CI: 0.36-0.87; OR= 0.63, 95% CI: 0.42-0.95; and OR= 0.66, 95% CI: 0.44-0.99, respectively), while only low intake of red meat was inversely associated with non-advanced adenomas (OR= 0.71, 95% CI: 0.49-0.97).
CONCLUSION
A better adherence to the MD, specifically low intake of sugar-sweetened beverages and red meat as well as high intake of fish, is related to lower odds for advanced polyps.
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