Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial
European journal of clinical nutrition, 2008•nature.com
Objectives: To assess the effect of two similar olive oils, but with differences in their phenolic
compounds (powerful antioxidant compounds), on inflammatory markers in stable coronary
heart disease patients. Design: Placebo-controlled, crossover, randomized trial. Setting:
Cardiology Department of Hospital del Mar and Institut Municipal d'Investigaci� M�dica
(Barcelona). Subjects: Twenty-eight stable coronary heart disease patients. Interventions: A
raw daily dose of 50 ml of virgin and refined olive oil (ROO) was sequentially administered�…
compounds (powerful antioxidant compounds), on inflammatory markers in stable coronary
heart disease patients. Design: Placebo-controlled, crossover, randomized trial. Setting:
Cardiology Department of Hospital del Mar and Institut Municipal d'Investigaci� M�dica
(Barcelona). Subjects: Twenty-eight stable coronary heart disease patients. Interventions: A
raw daily dose of 50 ml of virgin and refined olive oil (ROO) was sequentially administered�…
Abstract
Objectives:
To assess the effect of two similar olive oils, but with differences in their phenolic compounds (powerful antioxidant compounds), on inflammatory markers in stable coronary heart disease patients.
Design:
Placebo-controlled, crossover, randomized trial.
Setting:
Cardiology Department of Hospital del Mar and Institut Municipal d’Investigaci� M�dica (Barcelona).
Subjects:
Twenty-eight stable coronary heart disease patients.
Interventions:
A raw daily dose of 50 ml of virgin and refined olive oil (ROO) was sequentially administered over two periods of 3-weeks, preceded by 2-week washout periods in which ROO was used.
Results:
Interleukin-6 (P< 0.002) and C-reactive protein (P= 0.024) decreased after virgin olive oil intervention. No changes were observed in soluble intercellular and vascular adhesion molecules, glucose and lipid profile.
Conclusions:
Consumption of virgin olive oil, could provide beneficial effects in stable coronary heart disease patients as an additional intervention to the pharmacological treatment.
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