[HTML][HTML] Branched-chain amino acid catabolism in exercise and liver disease

…, M Shiraki, T Murakami, J Sato, H Kobayashi…�- The Journal of�…, 2006 - Elsevier
Branched-chain α-keto acid dehydrogenase (BCKDH) complex, the enzyme catalyst for the
second step of the BCAA catabolic pathway, plays a central role in the regulation of BCAA …

[HTML][HTML] Modulations of Muscle Protein Metabolism by Branched-Chain AminoAcids in Normal and Muscle-Atrophying Rats

H Kobayashi, H Kato, Y Hirabayashi, H Murakami…�- The Journal of�…, 2006 - Elsevier
It has been shown that BCAAs, especially leucine, regulate skeletal muscle protein metabolism.
However, it remains unclear how BCAAs regulate muscle protein metabolism and lead …

[HTML][HTML] A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly

CS Katsanos, H Kobayashi…�- American Journal�…, 2006 - journals.physiology.org
This study was designed to evaluate the effects of enriching an essential amino acid (EAA)
mixture with leucine on muscle protein metabolism in elderly and young individuals. Four (2 …

[HTML][HTML] Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults

E Volpi, H Kobayashi, M Sheffield-Moore…�- The American journal of�…, 2003 - Elsevier
Background Nutritional supplementation may be used to treat muscle loss with aging (sarcopenia).
However, if physical activity does not increase, the elderly tend to compensate for the …

[HTML][HTML] Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids

CS Katsanos, H Kobayashi, M Sheffield-Moore…�- The American journal of�…, 2005 - Elsevier
Background:Previous evidence suggests that aging in healthy persons does not result in
decreased incorporation of muscle proteins after a bolus ingestion of 15 g essential amino …

Effects of exercise and amino acid supplementation on body composition and physical function in community‐dwelling elderly Japanese sarcopenic women: a�…

…, K Saito, H Yoshida, H Kobayashi…�- Journal of the�…, 2012 - Wiley Online Library
Objectives To evaluate the effectiveness of exercise and amino acid supplementation in
enhancing muscle mass and strength in community‐dwelling elderly sarcopenic women. …

[HTML][HTML] Nutraceutical effects of branched-chain amino acids on skeletal muscle

…, J Sato, T Murakami, N Shimomura, H Kobayashi…�- The Journal of�…, 2006 - Elsevier
BCAA catabolism in skeletal muscle is regulated by the branched-chain α-keto acid
dehydrogenase (BCKDH) complex, located at the second step in the BCAA catabolic pathway. The …

Effect of amino acid supplementation on muscle mass, strength and physical function in elderly

E B�rsheim, QUT Bui, S Tissier, H Kobayashi…�- Clinical nutrition, 2008 - Elsevier
BACKGROUND & AIMS: With advancing age there is a gradual decline in muscle mass,
strength and function. The aim of this study was to determine if regular intake of a nutritional …

Branched-chain amino acid supplementation before squat exercise and delayed-onset muscle soreness

…, N Shimomura, H Kobayashi…�- …�journal of sport�…, 2010 - journals.humankinetics.com
The authors examined the effect of branched-chain amino acid (BCAA) supplementation on
squat-exercise-induced delayed-onset muscle soreness (DOMS) using 12 young, healthy, …

Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B

H Kobayashi, E B�rsheim…�- American Journal�…, 2003 - journals.physiology.org
We have examined the effect of a hemodialysis-induced 40% reduction in plasma amino
acid concentrations on rates of muscle protein synthesis and breakdown in normal swine. …