This whole question assumes that the canonical Net weapon used for immobilizing a Large creature, is 10ft across; if your answer is based on a presumption that a net weapon isn't 10ft across, please cite evidence to support such a ruling (RAW strongly preferred).
TLDR: All the info about the size of a net, indicates 10×10, & attacks can target a location & then hit ¿(unseen)? creature(s) in that location, so it seems one could target a 10×10 area with a net... correct?
Due to disadvantage on ranged (thrown) attacks within 5ft & the net's range of 5ft, it seems the net has become notorious as a sub-optimal choice of weapon, but if there's any possibly of hitting any-&-all creatures inside a 10×10 area, that seems like a significant note for analyzing optimal usage.
The rules for Making an Attack (PHB p193), ostensibly allow you to target a creature, object, or location:
(emphasis mine)
Whether you're striking with a melee weapon, firing a weapon at range, or making an attack roll as part of a spell, an attack has a simple structure.
Choose a target. Pick a target within your attack's range: a creature, an object, or a location.
Determine modifiers. The DM determines whether the target has cover and whether you have advantage or disadvantage against the target. In addition, spells, special abilities, and other effects can apply penalties or bonuses to your attack roll.
Resolve the attack. You make the attack roll. On a hit, you roll damage, unless the particular attack has rules that specify otherwise. Some attacks cause special effects in addition to or instead of damage.
If there's ever any question whether something you're doing counts as an attack, the rule is simple: if you're making an attack roll, you're making an attack.
The item (weapon) listing for a net (PHB p149 & OpenSRD), has a special property in place of damage on a hit:
A Large or smaller creature hit by a net is restrained until it is freed. A net has no effect on creatures that are formless, or creatures that are Huge or larger.
A creature can use its action to make a DC 10 Strength check, freeing itself or another creature within its reach on a success. Dealing 5 slashing damage to the net (AC 10) also frees the creature without harming it, ending the effect and destroying the net.
When you use an action, bonus action, or reaction to attack with a net, you can make only one attack regardless of the number of attacks you can normally make.
Large creatures occupy a 10×10 space, & the net traps all assume a 10ft net, & personally it looks pretty silly to me when I picture a Large creature getting restrained by a 5ft net (perhaps by a bolo).
The DMG & XGE listings for a Falling Net & a Net Trap, both affect a 10x10 area:
Falling Net (DMG p122 & SRD)
Mechanical trap
This trap uses a trip wire to release a net suspended from the ceiling.
The trip wire is 3 inches off the ground and stretches between two columns or trees. The net is hidden by cobwebs or foliage. The DC to spot the trip wire and net is 10. A successful DC 15 Dexterity check using thieves' tools breaks the trip wire harmlessly. A character without thieves' tools can attempt this check with disadvantage using any edged weapon or edged tool. On a failed check, the trap triggers.When the trap is triggered, the net is released, covering a 10-foot-square area. Those in the area are trapped under the net and restrained, and those that fail a DC 10 Strength saving throw are also knocked prone.
A creature can use its action to make a DC 10 Strength check, freeing itself or another creature within its reach on a success. The net has AC 10 and 20 hit points. Dealing 5 slashing damage to the net (AC 10) destroys a 5-foot-square section of it, freeing any creature trapped in that section.
Net Trap (XGE p113)
Simple trap (level 1–4, dangerous threat)
Goblins, with their propensity to enslave their enemies, prefer traps that leave intruders intact so the victims can be put to work in the mines or elsewhere.Trigger. A trip wire strung across a hallway is rigged to a large net. If the trip wire is broken, the net falls on intruders. An iron bell is also rigged to the trip wire. It rings when the trap activates, alerting nearby guards.
Effect. A net covering a 10-foot-by-10-foot area centered on the trip wire falls to the floor as a bell rings. Any creature fully within this area must succeed on a DC 15 Dexterity saving throw or be restrained. A creature can use its action to make a DC 10 Strength check to try to free itself or another creature in the net. Dealing 5 slashing damage to the net (AC 10, 20hp) also frees a creature without harming the creature.
Countermeasures. A successful DC 15 Wisdom (Perception) check reveals the trip wire and the net. A successful DC 15 Dexterity check using thieves' tools disables the trip wire without causing the net to drop or the bell to ring; failing the check causes the trap to activate.
Again, absent any actual text to such effect, it seems silly to me to presume a mere 5ft net: When have we even seen such a small net depicted or used in actual combat? Particularly for a Large creature controlling a 10×10 space, a 10×10 net seems both a reasonable presumption & the most supported by the texts provided.
A net attack targeting a single creature is widely considered grossly sub-optimal, & a real net's minimum necessary area to reduce a Large creature's speed to zero, is pretty close to 8 or 10ft if we're being even a little bit realistic. A net weapon less than 10ft across for stopping Large creatures, both lacks believability & lacks support within the canonical texts that mention nets & their uses. Is there any 5e attestation for nets being smaller than 10ft?
Thus, it seems well supported that as a weapon, a typical net is 10ft×10ft, to cover the area controlled by a Large creature.
As seen in point 1 of the PHB rules for making an attack, the rules expressly allow an attack roll to target a location; which has (almost!) no utility except AoE. (As @Jason_c_o points out, the OpenSRD section on Unseen Attackers and Combat, states that "guessing the target’s location" automatically misses a creature if it "isn’t in the location you targeted", heavily implying if not outright stating that an unseen creature can be hit when its location is targeted. Judging by this part of the rules, attacks targeting the presumed location of an unseen creature, could affect any creature(s) in that location.)
Of the five Spell Attacks that can target a location instead of specifically targeting only a creature or objects, none would have any effect unless creatures or objects in that location could be affected. Noteworthy?
Upon review, Bombs, grenades, Dynamite sticks, & other thrown AoE items that allow targeting a location, all use an Action, not an Attack roll.
Even weapon attacks with 10ft Reach, usually can't hit multiple creatures with one attack; the only thing supporting this idea of a thrown net hitting 4 creatures, is the premise of targeting a location 10ft across by throwing an item that's 10ft across, at that space, & the fact that I haven't found any attack of any kind that targets a location, except for the possibility of targeting the space an unseen creature is (believed to be) in. I understand that this is a thin line of reasoning, which is why I'm looking for any & all RAW relating to what can or cannot be hit by an attack that is targeting a location.
(Big thanks to @Jason_c_o, for providing citation that directly relates to Attacks that target locations.)
So, in the case of a thrown net 10ft across, an attack roll targeting a location, using a net 10ft square, could hit up to 4 unseen medium creatures. Is this true?
If not, why? What rule prevents an attack roll with an item that has a large area, from targeting an area its own size?
If so, should the GM count the wielder's attack roll against the AC of each creature within the 10ft area, with any creature hit becoming grappled by the net? Basically just like any other AoE attack roll?
Of course, "dealing 5 slashing damage to the net (AC 10) also frees the creature without harming it, ending the effect and destroying the net", so as soon as one creature cuts its way out, they're all freed; but I'm uncertain as to whether I've interpreted this mode of attack correctly in the first place: Is an AoE really allowed by RAW?
(In fact, even the +3 Net, still has AC 10 & gets destroyed by 5 slashing damage; extremely limited use for a Very Rare magic item!)
Essentially, this question is asking whether targeting a location with an item 10ft across, has a chance (AC) to hit those creatures. If a 10ft object is thrown at a space, do all creatures in that space have a chance to get hit?
Can the wielder of a net that is ten feet across, target a location, with an attack using that 10ft×10ft item, to hit 4 ¿(unseen)? medium creatures with one attack?