From my experience, W:tM games tends to go in two direction: It is either the "Court intrigue"EDIT - try gaining that Tremere's support to oust the Ventrue prince, get rid of local Brujah anarchs by sending them on suicide action towards Sabbath and frame the Malkavian primogen into breaking the Masquerade. Of course the Nosferatu are problem, because they simply KNOW what you are up to so... In this version the human world is just a backdrop, but from your question we know you DON'T want to go this way.(Cut since it was OT)
So try this approach:
"We are the monsters that try to stay humane, but look around, how monstrous are those calling themselves man". WoD (or any similar system) is a dark place, crime,corruption, poverty is much higher than in the real world: teenage girls sell themselves to run away from abusive parents and why you walking down the street someone is quite often willing to kill you just for your shoes. Show them that dark side: let them chase some gruesome serial killer believing that its some monster or fellow kindred, just to find its an ordinary man - I highly recommend you to watch the movie "8 mm", where detective chases masked killer who in the end looks like a dorky maths teacher. Make the players angry, let them start killing those low-lifes, let them feel like gods among mortals...and then in one moment let them realise, how low they themselves fell. On the nicer note, introduce them to some good humans: not corrupted cop, local social worker or simply a nice boy/girl that might start feeling something towards one of your players. Make them mingle with humans and play the masquerade (if you play WOD) - avoid being detected while still force them to feed.