Coronary artery calcium can predict all-cause mortality and cardiovascular events on low-dose CT screening for lung cancer.
Publication year
2012Source
American Journal of Roentgenology, 198, 3, (2012), pp. 505-11ISSN
Annotation
01 maart 2012
Publication type
Article / Letter to editor
![https://hdl.handle.net/2066/110713](https://cdn.statically.io/img/repository.ubn.ru.nl/themes/Mirage2//images/copy.png)
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Organization
Radiology
Journal title
American Journal of Roentgenology
Volume
vol. 198
Issue
iss. 3
Page start
p. 505
Page end
p. 11
Subject
N4i 3: Poverty-related infectious diseases ONCOL 5: Aetiology, screening and detection; Medical Imaging - Radboud University Medical CenterAbstract
OBJECTIVE: Performing coronary artery calcium (CAC) screening as part of low-dose CT lung cancer screening has been proposed as an efficient strategy to detect people with high cardiovascular risk and improve outcomes of primary prevention. This study aims to investigate whether CAC measured on low-dose CT in a population of former and current heavy smokers is an independent predictor of all-cause mortality and cardiac events. SUBJECTS AND METHODS: We used a case-cohort study and included 958 subjects 50 years old or older within the screen group of a randomized controlled lung cancer screening trial. We used Cox proportional-hazard models to compute hazard ratios (HRs) adjusted for traditional cardiovascular risk factors to predict all-cause mortality and cardiovascular events. RESULTS: During a median follow-up of 21.5 months, 56 deaths and 127 cardiovascular events occurred. Compared with a CAC score of 0, multivariate-adjusted HRs for all-cause mortality for CAC scores of 1-100, 101-1000, and more than 1000 were 3.00 (95% CI, 0.61-14.93), 6.13 (95% CI, 1.35-27.77), and 10.93 (95% CI, 2.36-50.60), respectively. Multivariate-adjusted HRs for coronary events were 1.38 (95% CI, 0.39-4.90), 3.04 (95% CI, 0.95-9.73), and 7.77 (95% CI, 2.44-24.75), respectively. CONCLUSION: This study shows that CAC scoring as part of low-dose CT lung cancer screening can be used as an independent predictor of all-cause mortality and cardiovascular events.
This item appears in the following Collection(s)
- Academic publications [241901]
- Electronic publications [127360]
- Faculty of Medical Sciences [91954]
- Open Access publications [102119]
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