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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 6
1947 6
1948 4
1949 6
1950 7
1951 10
1952 12
1953 7
1954 8
1955 18
1956 19
1957 23
1958 28
1959 43
1960 34
1961 44
1962 45
1963 43
1964 46
1965 24
1974 1
1975 2
1976 1
1983 1
1986 2
1987 2
1990 1
1992 1
1993 1
1994 1
1995 2
1996 1
2000 1
2001 3
2002 5
2003 4
2005 5
2006 5
2007 6
2008 7
2009 9
2010 15
2011 29
2012 127
2013 1382
2014 2602
2015 3167
2016 3299
2017 3522
2018 4183
2019 4393
2020 3500
2021 2792
2022 1273
2023 1016
2024 699

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Page 1
Healthy volunteers in first-in-human oncology drug development for small molecules.
de Las Heras B, Bouyoucef-Cherchalli D, Reeve L, Reichl A, Mandarino D, Flach S, Vidal L, van Brummelen EMJ, Steeghs N. de Las Heras B, et al. Br J Clin Pharmacol. 2022 Feb;88(4):1773-1784. doi: 10.1111/bcp.15092. Epub 2021 Oct 19. Br J Clin Pharmacol. 2022. PMID: 34558113 Free PMC article. Review.
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