Dysregulation of acyl carnitines, pentose phosphate pathway and arginine and ornithine metabolism are associated with decline in intrinsic capacity in Chinese older adults
- PMID: 38345670
- PMCID: PMC10861606
- DOI: 10.1007/s40520-023-02654-x
Dysregulation of acyl carnitines, pentose phosphate pathway and arginine and ornithine metabolism are associated with decline in intrinsic capacity in Chinese older adults
Abstract
Background: Intrinsic capacity is the combination of individual physical and mental abilities, reflecting the aging degree of the older adults. However, the mechanisms and metabolic characteristics of the decline in intrinsic capacity are still unclear.
Aims: To identify metabolic signatures and associated pathways of decline in intrinsic capacity based on the metabolite features.
Methods: We recruited 70 participants aged 77.19 ± 8.31 years. The five domains of intrinsic capacity were assessed by Short Physical Performance Battery (for mobility), Montreal cognition assessment (for cognition), 30-Item Geriatric Depression Scale (for psychology), self-reported hearing/visual impairment (for sensory) and Nutritional risk screening (for vitality), respectively. The serum samples of participants were analyzed by liquid chromatography-mass spectrometry-based metabolomics, followed by metabolite set enrichment analysis and metabolic pathway analysis.
Results: There were 50 participants with a decline in intrinsic capacity in at least one of the domains. A total of 349 metabolites were identified from their serum samples. Overall, 24 differential metabolites, 5 metabolite sets and 13 pathways were associated with the decline in intrinsic capacity.
Discussion: Our results indicated that decline in intrinsic capacity had unique metabolomic profiles.
Conclusion: The specific change of acyl carnitines was observed to be a feature of decline in intrinsic capacity. Dysregulation of the pentose phosphate pathway and of arginine and ornithine metabolism was strongly associated with the decline in intrinsic capacity.
Keywords: Aging; Functional decline; Intrinsic capacity; Metabolomics.
© 2024. The Author(s).
Conflict of interest statement
Author Bowen Li is employed by the LipidALL Technologies Company Limited. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Figures
![Fig. 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/10861606/bin/40520_2023_2654_Fig1_HTML.gif)
![Fig. 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/10861606/bin/40520_2023_2654_Fig2_HTML.gif)
![Fig. 3](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/10861606/bin/40520_2023_2654_Fig3_HTML.gif)
![Fig. 4](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/10861606/bin/40520_2023_2654_Fig4_HTML.gif)
Similar articles
-
Effects of personal and health characteristics on the intrinsic capacity of older adults in the community: a cross-sectional study using the healthy aging framework.BMC Geriatr. 2023 Oct 10;23(1):643. doi: 10.1186/s12877-023-04362-7. BMC Geriatr. 2023. PMID: 37817083 Free PMC article.
-
Serum Metabolic Profiles of Chinese Women With Perimenopausal Obesity Explored by the Untargeted Metabolomics Approach.Front Endocrinol (Lausanne). 2021 Sep 24;12:637317. doi: 10.3389/fendo.2021.637317. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34630316 Free PMC article.
-
Measurements of Intrinsic Capacity in Older Adults: A Scoping Review and Quality Assessment.J Am Med Dir Assoc. 2023 Mar;24(3):267-276.e2. doi: 10.1016/j.jamda.2022.09.011. Epub 2022 Nov 1. J Am Med Dir Assoc. 2023. PMID: 36332688 Review.
-
Metabolomic analyses reveal lipid abnormalities and hepatic dysfunction in non-human primate model for Yersinia pestis.Metabolomics. 2018 Dec 29;15(1):2. doi: 10.1007/s11306-018-1457-2. Metabolomics. 2018. PMID: 30830480 Free PMC article.
-
Translational Metabolomics of Head Injury: Exploring Dysfunctional Cerebral Metabolism with Ex Vivo NMR Spectroscopy-Based Metabolite Quantification.In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 25. In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 25. PMID: 26269925 Free Books & Documents. Review.
References
-
- Ageing and health. World Health Organization2022; www.who.int/zh/news-room/fact-sheets/detail/ageing-and-health.
-
- World report on ageing and health. World Health Organization2015; https://apps.who.int/iris/handle/10665/186463.
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources