Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations
- PMID: 34199588
- PMCID: PMC8228369
- DOI: 10.3390/nu13061915
Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations
Abstract
Creatine is one of the most studied and popular ergogenic aids for athletes and recreational weightlifters seeking to improve sport and exercise performance, augment exercise training adaptations, and mitigate recovery time. Studies consistently reveal that creatine supplementation exerts positive ergogenic effects on single and multiple bouts of short-duration, high-intensity exercise activities, in addition to potentiating exercise training adaptations. In this respect, supplementation consistently demonstrates the ability to enlarge the pool of intracellular creatine, leading to an amplification of the cell's ability to resynthesize adenosine triphosphate. This intracellular expansion is associated with several performance outcomes, including increases in maximal strength (low-speed strength), maximal work output, power production (high-speed strength), sprint performance, and fat-free mass. Additionally, creatine supplementation may speed up recovery time between bouts of intense exercise by mitigating muscle damage and promoting the faster recovery of lost force-production potential. Conversely, contradictory findings exist in the literature regarding the potential ergogenic benefits of creatine during intermittent and continuous endurance-type exercise, as well as in those athletic tasks where an increase in body mass may hinder enhanced performance. The purpose of this review was to summarize the existing literature surrounding the efficacy of creatine supplementation on exercise and sports performance, along with recovery factors in healthy populations.
Keywords: athletic performance; ergogenic aid; muscle damage; muscular adaptation; muscular power; recovery; resistance exercise; supplementation; training; weightlifting.
Conflict of interest statement
The authors of this manuscript received financial remuneration for preparing and reviewing this paper from the sponsor of the special issue, Alzchem. B.W., J.J.M., B.L., A.R.J., R.B.K., and C.M.K. have consulted with and received external funding from companies who sell certain dietary ingredients and have received remuneration from companies for delivering scientific presentations at conferences. A.R.J. and C.M.K. also write for online and other media outlets on topics related to exercise and nutrition. None of these entities had any role in the design of the paper, collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish this paper. R.B.K. has conducted industry-sponsored research on creatine, received financial support for presenting on creatine at industry-sponsored scientific conferences (including the ISSN), and served as an expert witness on cases related to creatine. Additionally, he serves as Chair of the Scientific Advisory Board for Alzchem, which manufactures creatine monohydrate.
Figures
Similar articles
-
Creatine Supplementation: An Update.Curr Sports Med Rep. 2021 Jul 1;20(7):338-344. doi: 10.1249/JSR.0000000000000863. Curr Sports Med Rep. 2021. PMID: 34234088
-
Effects of Dietary Nitrate Supplementation on Weightlifting Exercise Performance in Healthy Adults: A Systematic Review.Nutrients. 2020 Jul 26;12(8):2227. doi: 10.3390/nu12082227. Nutrients. 2020. PMID: 32722588 Free PMC article.
-
Multi-ingredient pre-workout supplements, safety implications, and performance outcomes: a brief review.J Int Soc Sports Nutr. 2018 Aug 8;15(1):41. doi: 10.1186/s12970-018-0247-6. J Int Soc Sports Nutr. 2018. PMID: 30089501 Free PMC article. Review.
-
International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine.J Int Soc Sports Nutr. 2017 Jun 13;14:18. doi: 10.1186/s12970-017-0173-z. eCollection 2017. J Int Soc Sports Nutr. 2017. PMID: 28615996 Free PMC article. Review.
-
Creatine and Caffeine: Considerations for Concurrent Supplementation.Int J Sport Nutr Exerc Metab. 2015 Dec;25(6):607-23. doi: 10.1123/ijsnem.2014-0193. Int J Sport Nutr Exerc Metab. 2015. PMID: 26219105 Review.
Cited by
-
Telecoaching: a potential new training model for Charcot-Marie-Tooth patients: a systematic review.Front Neurol. 2024 May 9;15:1359091. doi: 10.3389/fneur.2024.1359091. eCollection 2024. Front Neurol. 2024. PMID: 38784904 Free PMC article.
-
Effects of a Low Dose of Orally Administered Creatine Monohydrate on Post-Fatigue Muscle Power in Young Soccer Players.Nutrients. 2024 Apr 28;16(9):1324. doi: 10.3390/nu16091324. Nutrients. 2024. PMID: 38732571 Free PMC article. Clinical Trial.
-
The Effect of Prior Creatine Intake for 28 Days on Accelerated Recovery from Exercise-Induced Muscle Damage: A Double-Blind, Randomized, Placebo-Controlled Trial.Nutrients. 2024 Mar 20;16(6):896. doi: 10.3390/nu16060896. Nutrients. 2024. PMID: 38542807 Free PMC article. Clinical Trial.
-
The Effect of Creatine Nitrate and Caffeine Individually or Combined on Exercise Performance and Cognitive Function: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial.Nutrients. 2024 Mar 7;16(6):766. doi: 10.3390/nu16060766. Nutrients. 2024. PMID: 38542677 Free PMC article. Clinical Trial.
-
Advances in Understanding the Interplay between Dietary Practices, Body Composition, and Sports Performance in Athletes.Nutrients. 2024 Feb 19;16(4):571. doi: 10.3390/nu16040571. Nutrients. 2024. PMID: 38398895 Free PMC article. Review.
References
-
- Kerksick C.M., Wilborn C.D., Roberts M.D., Smith-Ryan A.E., Kleiner S.M., Jäger R., Collins R., Cooke M., Davis J.N., Galvan E., et al. ISSN exercise & sports nutrition review update: Research & recommendations. J. Int. Soc. Sports Nutr. 2018;15:38. doi: 10.1186/s12970-018-0242-y. - DOI - PMC - PubMed
-
- Kreider R.B., Kalman D.S., Antonio J., Ziegenfuss T.N., Wildman R., Collins R., Candow D.G., Kleiner S.M., Almada A.L., Lopez H.L. International Society of Sports Nutrition position stand: Safety and efficacy of creatine supplementation in exercise, sport, and medicine. J. Int. Soc. Sports Nutr. 2017;14:1–18. doi: 10.1186/s12970-017-0173-z. - DOI - PMC - PubMed
-
- Antonio J., Candow D.G., Forbes S.C., Gualano B., Jagim A.R., Kreider R.B., Rawson E.S., Smith-Ryan A.E., VanDusseldorp T.A., Willoughby D.S., et al. Common questions and misconceptions about creatine supplementation: What does the scientific evidence really show? J. Int. Soc. Sports Nutr. 2021;18:1–17. doi: 10.1186/s12970-021-00412-w. - DOI - PMC - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical