A low proportion n-6/n-3 PUFA diet supplemented with Antarctic krill (Euphausia superba) oil protects against osteoarthritis by attenuating inflammation in ovariectomized mice
- PMID: 34160515
- DOI: 10.1039/d1fo00056j
A low proportion n-6/n-3 PUFA diet supplemented with Antarctic krill (Euphausia superba) oil protects against osteoarthritis by attenuating inflammation in ovariectomized mice
Abstract
Osteoarthritis (OA), the most common form of arthritis, is characterized by cartilage destruction, and its incidence is much higher in the osteoporotic population. There is increasing evidence that the occurrence and development of OA are modulated by the dietary intake of polyunsaturated fatty acids (PUFA). This study investigated the effects of dietary PUFA, including n-3/n-6 PUFA proportion and the molecular form of n-3 PUFA, on OA using osteoporotic osteoarthritis dual model mice, where phospholipid type n-3 PUFA were specifically examined. The results revealed that a low proportion of n-6/n-3 PUFA in diets from 1 : 1 to 6 : 1 significantly improved the cartilage structure and inhibited articular cartilage polysaccharide loss. Furthermore, the low proportion n-6/n-3 PUFA diets inhibited the NF-κB signaling pathway by activating G-protein coupled receptor 120 (GPR120) to reduce inflammation and inhibit catabolism. Antarctic krill (Euphausia superba) oil (AKO), rich in phospholipid-type n-3 PUFA, had a better effect on OA than linseed oil (plant-derived n-3 PUFA), which may be due to peroxisome proliferator-activated receptor-gamma (PPAR γ). These findings suggested that the low proportion n-6/n-3 PUFA diets, particularly with AKO, alleviated inflammation and inhibited articular cartilage degeneration. Therefore, dietary intervention can be a potential treatment for OA.
Similar articles
-
The opposite effects of Antarctic krill oil and arachidonic acid-rich oil on bone resorption in ovariectomized mice.Food Funct. 2020 Aug 19;11(8):7048-7060. doi: 10.1039/d0fo00884b. Food Funct. 2020. PMID: 32813003
-
Effects of Edible Oils with Different n-6/n-3 PUFA Ratios on Articular Cartilage Degeneration via Regulating the NF-κB Signaling Pathway.J Agric Food Chem. 2020 Nov 11;68(45):12641-12650. doi: 10.1021/acs.jafc.0c05240. Epub 2020 Nov 2. J Agric Food Chem. 2020. PMID: 33136410
-
Peptides from Antarctic Krill ( Euphausia superba) Improve Osteoarthritis via Inhibiting HIF-2α-Mediated Death Receptor Apoptosis and Metabolism Regulation in Osteoarthritic Mice.J Agric Food Chem. 2019 Mar 20;67(11):3125-3133. doi: 10.1021/acs.jafc.8b05841. Epub 2019 Mar 12. J Agric Food Chem. 2019. PMID: 30798606
-
Omega-3 Supplementation and Its Effects on Osteoarthritis.Nutrients. 2024 May 28;16(11):1650. doi: 10.3390/nu16111650. Nutrients. 2024. PMID: 38892583 Free PMC article. Review.
-
Advances in Technologies for Highly Active Omega-3 Fatty Acids from Krill Oil: Clinical Applications.Mar Drugs. 2021 May 26;19(6):306. doi: 10.3390/md19060306. Mar Drugs. 2021. PMID: 34073184 Free PMC article. Review.
Cited by
-
TRPV Channels in Osteoarthritis: A Comprehensive Review.Biomolecules. 2024 Feb 29;14(3):292. doi: 10.3390/biom14030292. Biomolecules. 2024. PMID: 38540712 Free PMC article. Review.
-
Targeting the Inflammatory Hallmarks of Obesity-Associated Osteoarthritis: Towards Nutraceutical-Oriented Preventive and Complementary Therapeutic Strategies Based on n-3 Polyunsaturated Fatty Acids.Int J Mol Sci. 2023 May 26;24(11):9340. doi: 10.3390/ijms24119340. Int J Mol Sci. 2023. PMID: 37298291 Free PMC article. Review.
-
Dietary n-3/n-6 polyunsaturated fatty acid ratio modulates growth performance in spotted seabass (Lateolabrax maculatus) through regulating lipid metabolism, hepatic antioxidant capacity and intestinal health.Anim Nutr. 2023 Apr 25;14:20-31. doi: 10.1016/j.aninu.2023.04.005. eCollection 2023 Sep. Anim Nutr. 2023. PMID: 37234947 Free PMC article.
-
Recent Advance in Regulatory Effect of GRP120 on Bone Metabolism.Aging Dis. 2023 Oct 1;14(5):1714-1727. doi: 10.14336/AD.2023.0216. Aging Dis. 2023. PMID: 37196107 Free PMC article. Review.
-
Osteoarthritis: pathogenic signaling pathways and therapeutic targets.Signal Transduct Target Ther. 2023 Feb 3;8(1):56. doi: 10.1038/s41392-023-01330-w. Signal Transduct Target Ther. 2023. PMID: 36737426 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical