The effects of resveratrol intake on weight loss: a systematic review and meta-analysis of randomized controlled trials
- PMID: 30421960
- DOI: 10.1080/10408398.2018.1529654
The effects of resveratrol intake on weight loss: a systematic review and meta-analysis of randomized controlled trials
Abstract
This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of resveratrol intake on weight loss. We searched the following databases until July 2018: MEDLINE, EMBASE, Web of Science and Cochrane Central Register of Controlled Trials. Data were pooled using the inverse variance method and expressed as standardized mean difference (SMD) with 95% confidence intervals (95% CI). Out of 831 reports, 36 RCTs were eligible for including to our meta-analysis. The pooled results, using random-effects model showed that resveratrol supplementation significantly decreased body weight (SMD = -0.17; 95% CI, -0.33, -0.01; P = 0.03; I2: 62.6), body mass index (BMI) (SMD = -0.20; 95% CI, -0.35, -0.05; P = 0.01; I2: 60.6), fat mass (SMD = -0.32; 95% CI, -0.62, -0.03; P = 0.03; I2: 77.9) and waist circumference (WC) (SMD = -0.42; 95% CI, -0.68, -0.16; P = 0.001; I2: 75.2), and significantly increased lean mass (SMD = 1.21; 95% CI, 0.75, 1.67; P < 0.001; I2: 87.6). We found no significant effect of resveratrol administration on leptin (SMD = -0.20; 95% CI, -0.68, 0.27; P = 0.40; I2: 85.3) and adiponectin levels (SMD = 0.08; 95% CI, -0.39, 0.55; P = 0.74; I2: 91.0). Resveratrol supplementation significantly decreased body weight in obese patients (SMD -0.43; 95% CI, -0.60, -0.26) compared with other diseases (SMD 0.02; 95% CI, -0.29, 0.33), and type 2 diabetes mellitus (SMD -0.17; 95% CI, -0.37, 0.02). Overall, the current meta-analysis demonstrated that resveratrol intake significantly reduced weight, BMI, WC and fat mass, and significantly increased lean mass, but did not affect leptin and adiponectin levels.
Keywords: Resveratrol; meta-analysis; overweight; weight loss.
Similar articles
-
The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and meta-analysis of randomized controlled trials.Crit Rev Food Sci Nutr. 2019;59(11):1753-1766. doi: 10.1080/10408398.2018.1427044. Epub 2018 Feb 2. Crit Rev Food Sci Nutr. 2019. PMID: 29393665
-
The Effects of Curcumin on Weight Loss Among Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Front Pharmacol. 2019 Jun 12;10:649. doi: 10.3389/fphar.2019.00649. eCollection 2019. Front Pharmacol. 2019. PMID: 31249528 Free PMC article.
-
The effects of resveratrol supplementation on biomarkers of inflammation and oxidative stress among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials.Food Funct. 2018 Dec 13;9(12):6116-6128. doi: 10.1039/c8fo01259h. Food Funct. 2018. PMID: 30426122
-
Effect of dairy consumption on weight and body composition in adults: a systematic review and meta-analysis of randomized controlled clinical trials.Int J Obes (Lond). 2012 Dec;36(12):1485-93. doi: 10.1038/ijo.2011.269. Epub 2012 Jan 17. Int J Obes (Lond). 2012. PMID: 22249225 Review.
-
The Effects of Selenium Supplementation on Glucose Metabolism and Lipid Profiles Among Patients with Metabolic Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Horm Metab Res. 2017 Nov;49(11):826-830. doi: 10.1055/s-0043-119544. Epub 2017 Oct 9. Horm Metab Res. 2017. PMID: 28992632 Review.
Cited by
-
Effects of Mediterranean Diet, Curcumin, and Resveratrol on Mild-to-Moderate Active Ulcerative Colitis: A Multicenter Randomized Clinical Trial.Nutrients. 2024 May 16;16(10):1504. doi: 10.3390/nu16101504. Nutrients. 2024. PMID: 38794742 Free PMC article. Clinical Trial.
-
Mechanism of hypoxia-induced damage to the mechanical property in human erythrocytes-band 3 phosphorylation and sulfhydryl oxidation of membrane proteins.Front Physiol. 2024 Apr 19;15:1399154. doi: 10.3389/fphys.2024.1399154. eCollection 2024. Front Physiol. 2024. PMID: 38706947 Free PMC article.
-
Exploring the multimodal health-promoting properties of resveratrol: A comprehensive review.Food Sci Nutr. 2024 Jan 28;12(4):2240-2258. doi: 10.1002/fsn3.3933. eCollection 2024 Apr. Food Sci Nutr. 2024. PMID: 38628180 Free PMC article. Review.
-
Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment.Int J Mol Sci. 2024 Feb 25;25(5):2671. doi: 10.3390/ijms25052671. Int J Mol Sci. 2024. PMID: 38473918 Free PMC article. Review.
-
The Perfect Cup? Coffee-Derived Polyphenols and Their Roles in Mitigating Factors Affecting Type 2 Diabetes Pathogenesis.Molecules. 2024 Feb 6;29(4):751. doi: 10.3390/molecules29040751. Molecules. 2024. PMID: 38398503 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical