Inulin-type fructans and whey protein both modulate appetite but only fructans alter gut microbiota in adults with overweight/obesity: A randomized controlled trial
- PMID: 28730743
- DOI: 10.1002/mnfr.201700484
Inulin-type fructans and whey protein both modulate appetite but only fructans alter gut microbiota in adults with overweight/obesity: A randomized controlled trial
Abstract
Scope: Independently, prebiotics and dietary protein have been shown to improve weight loss and/or alter appetite. Our objective was to determine the effect of combined prebiotic and whey protein on appetite, body composition and gut microbiota in adults with overweight/obesity.
Methods and results: In a 12 week, placebo-controlled, double-blind study, 125 adults with overweight/obesity were randomly assigned to receive isocaloric snack bars of: (1) Control; (2) Inulin-type fructans (ITF); (3) Whey protein; (4) ITF + Whey protein. Appetite, body composition and gut microbiota composition/genetic potential were assessed. Compared to Control, body fat was significantly reduced in the Whey protein group at 12 wks. Hunger, desire to eat and prospective food consumption were all lower with ITF, Whey protein and ITF + Whey protein compared to Control at 12 wks. Microbial community structure differed from 0 to 12 wks in the ITF and ITF +Whey Protein groups (i.e. increased Bifidobacterium) but not Whey Protein or Control. Changes in microbial genetic potential were seen between Control and ITF-containing treatments.
Conclusion: Adding ITF, whey protein or both to snack bars improved several aspects of appetite control. Changes in gut microbiota may explain in part the effects of ITF but likely not whey protein.
Keywords: Appetite; Dairy protein; Gut microbiota; Inulin/oligofructose; Weight management.
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Similar articles
-
Prebiotics Reduce Body Fat and Alter Intestinal Microbiota in Children Who Are Overweight or With Obesity.Gastroenterology. 2017 Sep;153(3):711-722. doi: 10.1053/j.gastro.2017.05.055. Epub 2017 Jun 5. Gastroenterology. 2017. PMID: 28596023 Clinical Trial.
-
Effect of chicory inulin-type fructan-containing snack bars on the human gut microbiota in low dietary fiber consumers in a randomized crossover trial.Am J Clin Nutr. 2020 Jun 1;111(6):1286-1296. doi: 10.1093/ajcn/nqaa074. Am J Clin Nutr. 2020. PMID: 32320024 Clinical Trial.
-
Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women.Gut. 2013 Aug;62(8):1112-21. doi: 10.1136/gutjnl-2012-303304. Epub 2012 Nov 7. Gut. 2013. PMID: 23135760 Free PMC article. Clinical Trial.
-
Effects of inulin-type fructans on appetite, energy intake, and body weight in children and adults: systematic review of randomized controlled trials.Ann Nutr Metab. 2013;63(1-2):42-54. doi: 10.1159/000350312. Epub 2013 Jul 23. Ann Nutr Metab. 2013. PMID: 23887189 Review.
-
The Prebiotic Potential of Inulin-Type Fructans: A Systematic Review.Adv Nutr. 2022 Mar;13(2):492-529. doi: 10.1093/advances/nmab119. Epub 2023 Feb 10. Adv Nutr. 2022. PMID: 34555168 Free PMC article. Review.
Cited by
-
Potential Prebiotic Properties of Whey Protein and Glycomacropeptide in Gut Microbiome.Food Sci Anim Resour. 2024 Mar;44(2):299-308. doi: 10.5851/kosfa.2024.e12. Epub 2024 Mar 1. Food Sci Anim Resour. 2024. PMID: 38764509 Free PMC article. Review.
-
Non-digestible oligosaccharides-based prebiotics to ameliorate obesity: Overview of experimental evidence and future perspectives.Food Sci Biotechnol. 2023 Aug 9;32(14):1993-2011. doi: 10.1007/s10068-023-01381-3. eCollection 2023 Dec. Food Sci Biotechnol. 2023. PMID: 37860742 Review.
-
Consumption of yacon flour and energy-restricted diet increased the relative abundance of intestinal bacteria in obese adults.Braz J Microbiol. 2023 Dec;54(4):3085-3099. doi: 10.1007/s42770-023-01140-w. Epub 2023 Oct 9. Braz J Microbiol. 2023. PMID: 37807018 Clinical Trial.
-
Benefits of Fiber-Enriched Foods on Satiety and Parameters of Human Well-Being in Adults with and without Cardiometabolic Risk.Nutrients. 2023 Sep 6;15(18):3871. doi: 10.3390/nu15183871. Nutrients. 2023. PMID: 37764655 Free PMC article. Clinical Trial.
-
Effects of Animal and Vegetable Proteins on Gut Microbiota in Subjects with Overweight or Obesity.Nutrients. 2023 Jun 8;15(12):2675. doi: 10.3390/nu15122675. Nutrients. 2023. PMID: 37375578 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical