Creatine supplementation and resistance training in vulnerable older women: a randomized double-blind placebo-controlled clinical trial
- PMID: 24530883
- DOI: 10.1016/j.exger.2014.02.003
Creatine supplementation and resistance training in vulnerable older women: a randomized double-blind placebo-controlled clinical trial
Abstract
This study aimed to examine the efficacy of creatine supplementation, associated or not with resistance training, in vulnerable older women. A 24-week, double-blind, randomized, placebo-controlled trial was performed. Sixty subjects were assigned to compose the following groups: placebo (PL), creatine supplementation (CR), placebo with resistance training (PL+RT), and creatine supplementation with resistance training (CR+RT). The subjects were assessed at baseline and after 24weeks. The primary outcome was muscle strength, as assessed by one-repetition maximum (1-RM) tests. Secondary outcomes included appendicular lean mass, bone mass, biochemical bone markers, and physical function tests. The changes in 1-RM leg press were significantly greater in the CR+RT group (+19.9%) than in the PL (+2.4%) and the CR groups (+3.7%), but not than in the PL+RT group (+15%) (p=0.002, p=0.002, and p=0.357, respectively). The CR+RT group showed superior gains in 1-RM bench press (+10%) when compared with all the other groups (p≤0.05). The CR+RT group (+1.31%) showed greater appendicular lean mass accrual than the PL (-1.2%), the CR (+0.3%), and the PL+RT groups (-0.2%) (p≤0.05). The CR and the PL+RT groups experienced comparable gains in appendicular lean mass (p=0.62), but superior to those seen in the PL group. Changes in fat mass, bone mass and serum bone markers did not significantly differ between the groups (p>0.05). In conclusion, creatine supplementation combined with resistance training improved appendicular lean mass and muscle function, but not bone mass, in older vulnerable women. Clinicaltrials.gov: NCT01472393.
Keywords: Aging; Creatine; Diet; Elderly; Resistance training.
Copyright © 2014 Elsevier Inc. All rights reserved.
Similar articles
-
Strategic creatine supplementation and resistance training in healthy older adults.Appl Physiol Nutr Metab. 2015 Jul;40(7):689-94. doi: 10.1139/apnm-2014-0498. Epub 2015 Feb 26. Appl Physiol Nutr Metab. 2015. PMID: 25993883 Clinical Trial.
-
Creatine but not betaine supplementation increases muscle phosphorylcreatine content and strength performance.Amino Acids. 2012 Jun;42(6):2299-305. doi: 10.1007/s00726-011-0972-5. Epub 2011 Jul 9. Amino Acids. 2012. PMID: 21744011 Clinical Trial.
-
Effects of long-term low-dose dietary creatine supplementation in older women.Exp Gerontol. 2015 Oct;70:97-104. doi: 10.1016/j.exger.2015.07.012. Epub 2015 Jul 17. Exp Gerontol. 2015. PMID: 26192975 Clinical Trial.
-
Creatine supplementation during resistance training in older adults-a meta-analysis.Med Sci Sports Exerc. 2014 Jun;46(6):1194-203. doi: 10.1249/MSS.0000000000000220. Med Sci Sports Exerc. 2014. PMID: 24576864 Review.
-
Current Evidence and Possible Future Applications of Creatine Supplementation for Older Adults.Nutrients. 2021 Feb 26;13(3):745. doi: 10.3390/nu13030745. Nutrients. 2021. PMID: 33652673 Free PMC article. Review.
Cited by
-
Effect of Creatine Supplementation on Body Composition and Malnutrition-Inflammation Score in Hemodialysis Patients: An Exploratory 1-Year, Balanced, Double-Blind Design.Nutrients. 2024 Feb 23;16(5):615. doi: 10.3390/nu16050615. Nutrients. 2024. PMID: 38474743 Free PMC article. Clinical Trial.
-
Bibliometric and Visual Analysis of Global Research on Taurine, Creatine, Carnosine, and Anserine with Metabolic Syndrome: From 1992 to 2022.Nutrients. 2023 Jul 29;15(15):3374. doi: 10.3390/nu15153374. Nutrients. 2023. PMID: 37571314 Free PMC article. Review.
-
The role of nutraceuticals in heart failure muscle wasting as a result of inflammatory activity. The International Lipid Expert Panel (ILEP) Position Paper.Arch Med Sci. 2023 Jun 9;19(4):841-864. doi: 10.5114/aoms/167799. eCollection 2023. Arch Med Sci. 2023. PMID: 37560745 Free PMC article.
-
Sarcopenia in Menopausal Women: Current Perspectives.Int J Womens Health. 2022 Jun 23;14:805-819. doi: 10.2147/IJWH.S340537. eCollection 2022. Int J Womens Health. 2022. PMID: 35769543 Free PMC article. Review.
-
The impact of resistance training on body composition, muscle strength, and functional fitness in older women (45-80 years): A systematic review (2010-2020).Women (Basel). 2021 Sep;1(3):143-168. doi: 10.3390/women1030014. Epub 2021 Sep 14. Women (Basel). 2021. PMID: 35702064 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical