Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Aug;143(8):1283-92.
doi: 10.3945/jn.113.174920. Epub 2013 Jun 5.

Fruit and vegetable intakes are associated with lower risk of bladder cancer among women in the Multiethnic Cohort Study

Song-Yi Park  1 , Nicholas J Ollberding, Christy G Woolcott, Lynne R Wilkens, Brian E Henderson, Laurence N Kolonel
Affiliations

Fruit and vegetable intakes are associated with lower risk of bladder cancer among women in the Multiethnic Cohort Study

Song-Yi Park et al. J Nutr. 2013 Aug.

Abstract

Fruits and vegetables have been examined for their possible effects on the risk of bladder cancer, as they contain numerous nutrients, phytochemicals, and antioxidants with potentially anticarcinogenic properties. In a prospective analysis of 185,885 older adults participating in the Multiethnic Cohort Study, we examined whether the consumption of fruits and vegetables, or of nutrients concentrated in fruits and vegetables, was associated with bladder cancer risk. Cox proportional hazards models were used to calculate HRs and 95% CIs for bladder cancer in relation to dietary intakes. A total of 581 invasive bladder cancer cases (429 men and 152 women) were diagnosed over a mean follow-up period of 12.5 y. In women, total fruits and vegetables [HR = 0.35 (95% CI: 0.22, 0.56); highest vs. lowest quartile], total vegetables [HR = 0.49 (95% CI: 0.29, 0.83)], yellow-orange vegetables [HR = 0.48 (95% CI: 0.30, 0.77)], total fruits [HR = 0.54 (95% CI: 0.34, 0.85)], and citrus fruits [HR = 0.56 (95% CI: 0.34, 0.90)] were inversely associated with the risk of invasive bladder cancer in risk factor-adjusted models. In addition, women with the highest intakes of vitamins A, C, and E; the carotenoids α-carotene, β-carotene, and β-cryptoxanthin; and folate had a lower risk of bladder cancer. For men, no associations for fruits, vegetables, or nutrients were found overall, although inverse associations were observed for vegetable intake among current smokers, and in ethnic-specific analyses, for fruit and vegetable intake among Latinos specifically. Our findings suggest that greater consumption of fruits and vegetables may lower the risk of invasive bladder cancer among women and highlight the need for specific subgroup analyses in future studies.

PubMed Disclaimer

Conflict of interest statement

Author disclosures: S.-Y. Park, N. J. Ollberding, C. G. Woolcott, L. R. Wilkens, B. E. Henderson, and L. N. Kolonel, no conflicts of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. American Cancer Society. Cancer facts and figures 2012. Atlanta: American Cancer Society; 2012.
    1. Silverman DT, Devesa SS, Moore LE, Rothman N. Bladder cancer. In: Schottenfeld D, Fraumeni JF Jr. editors. Cancer epidemiology and prevention. 3rd ed. New York: Oxford University Press; 2006. p. 1101–27.
    1. Freedman ND, Silverman DT, Hollenbeck AR, Schatzkin A, Abnet CC. Association between smoking and risk of bladder cancer among men and women. JAMA. 2011;306:737–45. - PMC - PubMed
    1. Parkin DM. The global burden of urinary bladder cancer. Scand J Urol Nephrol Suppl. 2008:12–20. - PubMed
    1. Letašiovš S, Medve'ova A, Sovcikova A, Dusinska M, Volkovova K, Mosoiu C, Bartonova A. Bladder cancer, a review of the environmental risk factors. Environ Health. 2012;11 Suppl 1:S11. - PMC - PubMed

Publication types

MeSH terms