Milk thistle in liver diseases: past, present, future
- PMID: 20564545
- DOI: 10.1002/ptr.3207
Milk thistle in liver diseases: past, present, future
Abstract
Silybum marianum or milk thistle (MT) is the most well-researched plant in the treatment of liver disease. The active complex of MT is a lipophilic extract from the seeds of the plant and is composed of three isomer flavonolignans (silybin, silydianin, and silychristin) collectively known as silymarin. Silybin is a component with the greatest degree of biological activity and makes up 50% to 70% of silymarin. Silymarin is found in the entire plant but it is concentrated in the fruit and seeds. Silymarin acts as an antioxidant by reducing free radical production and lipid peroxidation, has antifibrotic activity and may act as a toxin blockade agent by inhibiting binding of toxins to the hepatocyte cell membrane receptors. In animals, silymarin reduces liver injury caused by acetaminophen, carbon tetrachloride, radiation, iron overload, phenylhydrazine, alcohol, cold ischaemia and Amanita phalloides. Silymarin has been used to treat alcoholic liver disease, acute and chronic viral hepatitis and toxin-induced liver diseases.
Copyright © 2010 John Wiley & Sons, Ltd.
Similar articles
-
A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos).Altern Med Rev. 2005 Sep;10(3):193-203. Altern Med Rev. 2005. PMID: 16164374 Review.
-
Milk thistle (Silybum marianum) for the therapy of liver disease.Am J Gastroenterol. 1998 Feb;93(2):139-43. doi: 10.1111/j.1572-0241.1998.00139.x. Am J Gastroenterol. 1998. PMID: 9468229 Review.
-
Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases.Phytother Res. 2018 Nov;32(11):2202-2213. doi: 10.1002/ptr.6171. Epub 2018 Aug 6. Phytother Res. 2018. PMID: 30080294 Review.
-
Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part I. Silymarin and its flavonolignans.Phytother Res. 2004 Feb;18(2):107-10. doi: 10.1002/ptr.1415. Phytother Res. 2004. PMID: 15022159
-
Milk thistle.Am Fam Physician. 2005 Oct 1;72(7):1285-8. Am Fam Physician. 2005. PMID: 16225032 Review.
Cited by
-
Milk thistle protects against non-alcoholic fatty liver disease induced by dietary thermally oxidized tallow.Heliyon. 2024 May 17;10(10):e31445. doi: 10.1016/j.heliyon.2024.e31445. eCollection 2024 May 30. Heliyon. 2024. PMID: 38818175 Free PMC article.
-
Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice.Nutrients. 2024 Apr 14;16(8):1169. doi: 10.3390/nu16081169. Nutrients. 2024. PMID: 38674860 Free PMC article.
-
Chromosome-level genome assembly of milk thistle (Silybum marianum (L.) Gaertn.).Sci Data. 2024 Apr 5;11(1):342. doi: 10.1038/s41597-024-03178-3. Sci Data. 2024. PMID: 38580686 Free PMC article.
-
Natural feed additives and bioactive supplements versus chemical additives as a safe and practical approach to combat foodborne mycotoxicoses.Front Nutr. 2024 Feb 19;11:1335779. doi: 10.3389/fnut.2024.1335779. eCollection 2024. Front Nutr. 2024. PMID: 38450227 Free PMC article. Review.
-
Dimethyl Bisphenolate Ameliorates Carbon Tetrachloride-Induced Liver Injury by Regulating Oxidative Stress-Related Genes.Molecules. 2023 Dec 7;28(24):7989. doi: 10.3390/molecules28247989. Molecules. 2023. PMID: 38138479 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous