A randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome composite score and bone mineral in older adults
- PMID: 19370038
- DOI: 10.1139/H08-142
A randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome composite score and bone mineral in older adults
Abstract
A randomized double-blind placebo controlled study design was used to assess the effects of flaxseed lignan complex supplementation during exercise training on a metabolic syndrome composite score and osteoporosis risk in older adults. A total of 100 subjects (>or=50 years) were randomized to receive flaxseed lignan (543 mg.day-1 in a 4050 mg complex) or placebo while completing a 6 month walking program (30-60 min.day-1, 5-6 days.week-1). Fasting serum glucose, triacylglycerol (TAG), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, total cholesterol, interleukin-6, and tumor necrosis factor-alpha were measured every 2 months, while body composition, bone mineral density, and resting blood pressure were assessed at baseline and at 6 months. A composite Z score of 6 risk factors for metabolic syndrome (fasting glucose, HDL cholesterol, TAG, abdominal adiposity, blood pressure, and inflammatory cytokines) was calculated at baseline and at 6 months. Men taking placebo increased metabolic syndrome composite Z score (p < 0.05), but there were no changes in the other groups. A significant group x sex x time interaction was noted for TAG (p = 0.017) and diastolic blood pressure (p = 0.046), with men taking flaxseed lignan decreasing diastolic blood pressure relative to men taking placebo, and men taking placebo increasing TAG relative to men taking flax lignan. There were no differences between groups for change in bone measures, body composition, lipoproteins, or cytokines. Males taking the flaxseed lignan complex reduced metabolic syndrome score relative to men taking placebo, but a similar trend was not seen in females. Flaxseed lignan had no effect on bone mineral density or content, body composition, lipoproteins, glucose, or inflammation.
Similar articles
-
No evidence of hypoglycemia or hypotension in older adults during 6 months of flax lignan supplementation in a randomized controlled trial: a safety evaluation.Pharm Biol. 2013 Jun;51(6):778-82. doi: 10.3109/13880209.2013.766220. Epub 2013 Apr 11. Pharm Biol. 2013. PMID: 23577799 Clinical Trial.
-
Influence of Flaxseed Lignan Supplementation to Older Adults on Biochemical and Functional Outcome Measures of Inflammation.J Am Coll Nutr. 2017 Nov-Dec;36(8):646-653. doi: 10.1080/07315724.2017.1342213. Epub 2017 Sep 18. J Am Coll Nutr. 2017. PMID: 28922068 Clinical Trial.
-
Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men.Nutr Res. 2010 Jul;30(7):441-6. doi: 10.1016/j.nutres.2010.06.004. Nutr Res. 2010. PMID: 20797475 Clinical Trial.
-
Flaxseed and cardiovascular health.J Cardiovasc Pharmacol. 2009 Nov;54(5):369-77. doi: 10.1097/FJC.0b013e3181af04e5. J Cardiovasc Pharmacol. 2009. PMID: 19568181 Review.
-
Flaxseed and its lignan and oil components: can they play a role in reducing the risk of and improving the treatment of breast cancer?Appl Physiol Nutr Metab. 2014 Jun;39(6):663-78. doi: 10.1139/apnm-2013-0420. Epub 2013 Dec 23. Appl Physiol Nutr Metab. 2014. PMID: 24869971 Review.
Cited by
-
Phytoestrogens and Health Effects.Nutrients. 2023 Jan 9;15(2):317. doi: 10.3390/nu15020317. Nutrients. 2023. PMID: 36678189 Free PMC article. Review.
-
The Lignan-Rich Fraction from Sambucus williamsii Hance Exerts Bone Protective Effects via Altering Circulating Serotonin and Gut Microbiota in Rats.Nutrients. 2022 Nov 8;14(22):4718. doi: 10.3390/nu14224718. Nutrients. 2022. PMID: 36432403 Free PMC article.
-
The Effect of Flaxseed Oil Supplementation on Body Composition and Inflammation Indices in Overweight Adults With Pre-Diabetes.Nutr Metab Insights. 2022 Jun 29;15:11786388221090083. doi: 10.1177/11786388221090083. eCollection 2022. Nutr Metab Insights. 2022. PMID: 35799617 Free PMC article.
-
Role of Phytoestrogen-Rich Bioactive Substances (Linum usitatissimum L., Glycine max L., Trifolium pratense L.) in Cardiovascular Disease Prevention in Postmenopausal Women: A Systematic Review and Meta-Analysis.Nutrients. 2022 Jun 14;14(12):2467. doi: 10.3390/nu14122467. Nutrients. 2022. PMID: 35745197 Free PMC article.
-
Dietary lignans, plasma enterolactone levels, and metabolic risk in men: exploring the role of the gut microbiome.BMC Microbiol. 2022 Mar 29;22(1):82. doi: 10.1186/s12866-022-02495-0. BMC Microbiol. 2022. PMID: 35350985 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical