Maurice van den Bosch

New SGLT2 inhibitor meta-analysis on effect on HF- across diff populations  https://lnkd.in/e8b8KK7h

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Ten Commandments from ESC on DM and CV disease.

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New research from Technology in Cancer Research & Treatment: Comparison of Doses to Parotid, Temporomandibular Joint, and Pharyngeal Constrictor Muscles Using Different Techniques in Radiotherapy for Oropharyngeal Cancer https://lnkd.in/gBW9UQNr #cancerresearch #cancertechnology #technology #openaccess #SAGEresearch

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There is still time to register and learn the future impact of AI in Respiratory Failure management

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https://lnkd.in/gfScjhaf      Article title: New methods for bleeding monitoring   Author(s): Omer Baygin; Ozlem Kaya; Ayten Saracoglu; Kemal Tolga Saracoglu   Journal: Global Journal of Anesthesiology   Journal ISSN: 2455-3476 Abstract: Bleeding is a potentially preventable reason of the death among patients during major surgery. Appropriate monitorization is necessary to perform optimum resuscitation. However, conventional coagulation tests have some limitations. In recent years, point of care (POC) tests has been developed to improve patient safety in the presence of clinical bleeding POC tests measure viscoelastic properties of full-thickness clot formation in the beginning of bleeding. In this review, both of advantage and disadvantage of monitorization tests during bleeding management is explained. #Bleeding #PointOfCareTest #Coagulation #Anesthesia #AmbulatoryAnesthesia #AnestheticPharmacology #CardiovascularAnesthesia #CriticalCare #Trauma #NeurosurgicalAnesthesia #ObstetricAnesthesia #Anesthesiology #PainMedicine #RegionalAnesthesia #PainManagement #CardiothoracicAnesthesia #VascularAnesthesia #ClinicalAnesthesia #ObstetricAnesthesia #PerinatalPhysiology #Pharmacology #Neuroscience #CellularBiology #MolecularBiology #TissueEngineering #TranslationalResearch #NeuropathicPain #Stimulation #Electroanalgesia #MusculoskeletalPain #PTSD #CRPS #DiabeticNeuropathicPain #PostoperativePain #ChronicPain #CancerPain #Resuscitation #BloodTransfusion #RespiratoryTherapy #PainRelief #CriticalCare #Nursing #PeriAnesthesiaNursing #Dermatology #Psychology #Cardiology #CardiovascularMedicine #PulmonaryMedicine #RespiratoryMedicine #AmbulatorySurgery #PreadmissionTesting #PostAnesthesiaCare #PainManagement

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Hypofractionated Radiation Therapy A Cross-sectional Survey Study of US Radiation Oncologists https://lnkd.in/dbdGQQj3

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our new article has been published wish to thank pegah sahafi Kamran Khazaeni Ehsan Khadivi Intra-operative lymphatic mapping and sentinel node biopsy in laryngeal carcinoma using radiotracer injection Objective: The purpose of this study was to determine the value of sentinel lymph node biopsy (SLNB) in the laryngeal SCC, using intra-operative peri-tumoral injection of Tc-99m-phytate. Methods: Patients with biopsy-proven squamous cell carcinoma of the larynx were included. On the day of surgery, after anesthesia induction, suspension laryngoscopy was performed to inject 74 MBq/0.4 ml Tc-99m-phytate in four aliquots into the sub-mucosal peri-tumoral location. After a 10-min wait, a portable gamma probe was used to locate sentinel nodes. Subsequently, all patients underwent laryngectomy and neck dissection. Both sentinel nodes and non-sentinel nodes were examined using hematoxylin and eosin (H&E) staining. Results: Twenty-six patients with a diagnosis of laryngeal carcinoma were included in the study. The SLN detection rate was 65.4%, with a 100% detection rate in the supraglottic region and a 52.6% detection rate for glottis/transglottic patients. Permanent pathology results showed lymph node involvement in four patients, but only one patient had a negative result in the SLNB, resulting in an overall false negative rate of 25%. The sensitivity of the SLN technique was 75% overall, 100% in the supraglottic region, and 67% in the glottis/transglottic region. Conclusion: The accuracy and feasibility of SLNB may be related to the location of the tumors in the larynx. For supraglottic tumors, the technique seems to be feasible with a low false negative rate. For glottis/transglottic tumors, both the detection rate and false negative rate seem to be suboptimal. Further studies are needed to validate our results #nuclear_medicine #lymphoscintigraphy #oncology

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I would like to offer a comment on the conclusion the authors have made in this paper: Although the authors say that their new risk score would change eligibility, a huge issue with that argument is that the ACC/AHA guidelines calling for use of statins beginning at 7.5% are based on the old calculator. In fact in the clinical trials there’s benefit of statins of equal proportion when people are 5% (as assessed in the CTT analysis of low risk patients - attached). and so the 7.5% was an arbitrary cut point, using the old calculator. If this new PREVENT risk calculator is to be used for statin eligibility, one would need to apply this new score in the clinical trials and see down to what percent risk on their score that statin benefit is seen and then adjust the guidelines accordingly. That hasn't been done and so their notion that 17 million people are no longer eligible for statins in not evidence based but rather applying a new score to a guideline based on the old score.

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Our chapter, "𝑳𝒐𝒘-𝒅𝒐𝒔𝒆 𝑹𝒂𝒅𝒊𝒂𝒕𝒊𝒐𝒏 𝑻𝒉𝒆𝒓𝒂𝒑𝒚 𝒇𝒐𝒓 𝑪𝑶𝑽𝑰𝑫-19 𝑨𝒔𝒔𝒐𝒄𝒊𝒂𝒕𝒆𝒅 𝑷𝒏𝒆𝒖𝒎𝒐𝒏𝒊𝒂: 𝑰𝒔 𝑻𝒉𝒆𝒓𝒆 𝑺𝒖𝒇𝒇𝒊𝒄𝒊𝒆𝒏𝒕 𝑺𝒖𝒑𝒑𝒐𝒓𝒕𝒊𝒏𝒈 𝑬𝒗𝒊𝒅𝒆𝒏𝒄𝒆?," is officially published in the book "𝑳𝒐𝒘 𝑫𝒐𝒔𝒆 𝑹𝒂𝒅𝒊𝒂𝒕𝒊𝒐𝒏 𝒊𝒏 𝑯𝒆𝒂𝒍𝒕𝒉 𝒂𝒏𝒅 𝑫𝒊𝒔𝒆𝒂𝒔𝒆" edited by Badri Narain Pandey, Nagraj G. Huilgol. This project wouldn't have been possible without the invaluable collaboration of my esteemed colleagues.

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The next pages of this document show how one #DailyCDM question addresses the highlighted parts in the #MCCQE1 objective below. #meded #mccqe #mcc #nac

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PSA-Density and PIRADSv2 classification in risk nomograms can provide highly relevant information to increase the accuracy in the diagnosis of PC and ST.

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Our latest publication in BMC Gastroenterology: Clinical and endoscopic characteristics of patients undergoing gastrointestinal endoscopic procedures in Egypt: a nationwide multicenter study This study aimed to evaluate the clinico-demographic data, indications, and endoscopic findings of Egyptian patients undergoing gastrointestinal endoscopic procedures in various regions of Egypt. You can find it at the following link: https://lnkd.in/dN3TtYMK Mohamed El-Kassas Mohamed Elbadry

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Class I occlusion (right side) and Class II occlusion (left side) Establishing 9 occlusal points of contact (5 functional and stabilizing points in the form of 2 tripods and 4 supporting points for load distribution) with respect to 7 mandibular movements (3 primary, 2 mixed and 2 border movements) following the occlusal compass on the upper first molars. 🐉😊 #united_dragons_of_function #occlusal_compass #dental_occlussion #dieter_schulz #natural_waxingup_technique #natural_and_functional_reconstruction #natural_and_functional_prosthetics #NAT #NFR #NFP

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📣 New Technology in Cancer Research & Treatment article on Bone Marrow Sparing by Intensity Modulated Proton Beam Therapy in Postoperative Irradiation of Gynecoligoc Maligninacies, Wark et al., University Hospital Heidelberg (UKHD) https://shorturl.at/R23U4 #uterinecancer #cervicalcancer #endometrialcancer #radiotherapy OncoDaily

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Very late onset Lupus (>60) differs being less female, less arthritis/dz activity, lower dsDNA, C3, SSA, SSB and ANA but more Sjogrens & RA? Single clinic study of 845 SLE - jSLE (<18), aSLE (18-49), lSLE (50-60), and vlSLE (>60). vlSLE had lowest survival (20yrs)

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So glad we’re measuring the abilities/limitations of POC MRI; can make a legitimate use-case in acute neurology. Forget the big magnet—let’s compare the tech within its potential use, POC MRI sensitivity is notably superior to NCCT (it’s been shown that the NCCT sensitivity for ischemic strokes older than 12 hours is only ~16%); NCCT’s value is in ruling-out ICH (for this time window >84% sensitivity). And, considering most systems’ protocol, better imaging for both is important, because many patients are denied opportunity for acute intervention if LKW unobtainable and/or >12-24hrs. How about this option—taking advantage of both their strengths: For clinical diagnosis of AIS and presumed onset<72hrs (most folks in the ED) but “Inaccurate Last Known Well” (ILKW, LKW>24hrs or no historical context), 1. NCCT first, 2. on return to ED into dedicated POC MRI. 3. If no T2 on FLAIR give systemic rapid fibrinolytic. 4. Does DWI characteristics suggest endovascular intervenable pathology? Decide to go to lab. With mobile PACS platforms, eg. VIZ.AI & RAPID, now able to view MRI, decision making with this setup could be in real time and easily incorporated in all thrombectomy capable centers. If anyone else has POC-MRI in their ED and want to write this up with me, give me a call 🙌🏽

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