I myself don't have any good way (this would be the perfect way) to do it, even while there are some options.
Be it for responses, reputation, interesting stuff...
I couldn't find any simple RSS solution, the e-mail is just about answers to questions, and refreshing the "recent" will clear up on the second refresh.
I can't check the web site daily and I'm still looking for solutions here. So I'd like to know how you people do it. Not how I should do.
edit: I was just tracking this question on superuser and Josh K, who's no newbie, edited his answer as a reply to my comment. But I would never know this unless I checked the question itself! So, adding to the question, how would you keep track of that?
edit2: Reenforcing, I wish to know how you, who's answering this, do to keep track. It seems like nobody who does it different cares to post it, or maybe nobody does. The answers so far are rather telling me how I should do. But even with all that suggestions, I'm having issues to keep track of responses, answers and conversations on all different StackExchange sites that I participate: unity3D, superuser, meta, and a lil bit of others. And I really needed a good way to get notified here just because I wish to (A) respond faster and (B) actually see who responded me. I'm just hoping this isn't just me.
PS: this edit is also a perfectly good example of how I would use a folding block. I'd just fold this whole edit.
edit3: While there's no emails, Stack Exchange Notifier (google chrome addon) has been good.
edit4: SEN advised on last edit stopped working a while ago, and my only way was the Global Inbox. Now I've got a new way (see below)! Main issue is it's Mac-only.