Wikipedia to the help: http://en.wikipedia.org/wiki/Three-parent_baby: > Three-parent babies are human offspring with three genetic parents, created through a > specialized form of In vitro fertilisation in which the future baby's mitochondrial DNA > comes from a third party. See also http://www.bbc.com/news/magazine-28986843 for the young case of Mrs. Saarinen. Such a child would have DNA from three people. If one genetic source would be a 100% Cherokee and others 0% Cherokees, he or she would be 1/3 Cherokee. Her/his offspring would be 1/6 Cherokee and subsequent offspring 1/12 Cherokee provided later parents were 0% non-Cherokees. All this is assuming rather loose-minded mathematical reasoning or simplistic reduction of complexities of genetics. As this controversial treatment is rather new, to strictly answer the question, the self-claimed 1/12 cherokee had to have some other avenue to his stated fractional Cherokee legacy.