Bloom, Iggy and Reynolds rally around Max as he deals with the fallout from Helen's decision; Bloom gives extra space to Leyla but is in for a surprise; Reynolds and Wilder help a young terminal patient realise his dream to star in a Bollywood show.
Max tests a bold new cost-saving programme that could help New Amsterdam; Wilder struggles with a patient's decision to refuse life-saving surgery; Reynolds comes to a realisation about his father's behaviours; Iggy takes the leap into online dating.
An explosion at a wedding ceremony sends a stream of injured partygoers into New Amsterdam; Max and Wilder scramble to find a rare blood type to save the groom; in helping a girl out of a catatonic state, Iggy learns the truth about the wedding.
Max mandates a personal health day for the staff and is met with surprising resistance; Reynolds is intrigued by a persuasive new member of the staff; Bloom struggles after being taken off an essential medication; Iggy goes on his first date.
Max endeavours to save a nurse who has become the subject of a dangerous malpractice probe; Reynolds goes the extra mile to help a group of patients who are being poisoned in their own building; Bloom makes a startling admission to her sister.
Max goes on a mission to make New York safer; Iggy helps a family come to terms with their deaf child's inability to communicate.
Ryan Eggold
Dr. Max Goodwin
Janet Montgomery
Dr. Lauren Bloom
Jocko Sims
Dr. Floyd Reynolds
Sandra Mae Frank
Dr. Elizabeth Wilder
Tyler Labine
Dr. Iggy Frome