Answer:
Noted by whom? Columbus died in his bed, surrounded by his family and friends, well off due to profits from his discoveries. ( for more than a decade he received lucrative trade royalties from the Indies).

Still, I can see how that statement is true. Columbus died, after suffering a disabling illness for years which left him drained physically and emotionally. He died disgraced and out of favor with the royal family who's support formed his most important partnership for his most famous voyages. He died denied perpetual royalties to his newly discovered territory and trade route. Finally Christopher Columbus died before his greatest discovery was itself understood.

disabling illness
Columbus suffered from reactive arthritis or Reiter’s syndrome which caused him to bleed from his eyes, and have soar arthritic joints; making him appear possessed and physically difficult for him to get around. His malady was likely caused by hardships which occurred during one of his voyages, eating poorly prepared or rotten food and suffering unclean circumstances. This disease was poorly understood and misdiagnosed in Columbus's time. His medical resources in 1500's were insufficient to treat the malady and it overt symptoms left him exhausted and with strange characteristics like bleeding from his eyes both of which were debilitating professionally and personally.

Disgraced
Columbus was recalled from office, first Spanish governor of the Indies in 1499 by Queen Isabella and King Ferdinand after reports of tyranny conducted by him reached the royal couple. He would never again be appointed to position by the Spanish royal court.

Columbus had made his fourth and final passage to the Indies in in 1502, three years after being removed as Governor. Columbus was searching for the Strait of Malacca, the passage to the Indian Ocean which he of coarse never found. This inability to find the path to Asia from his Indies cast a shadow over his discovery of the reported new trade route he believed he had found.

I can see how he would have been perceived a failure. Even though he had accumulated great fame and wealth from his discoveries; he was out of favor, disgraced, and denied his monetary benefits of his discovery and the acknowledgement for those discoveries which history would remember him by.

Answer:
Noted by whom? Columbus died in his bed, surrounded by his family and friends, well off due to profits from his discoveries. (For more than a decade he received lucrative trade royalties from the Indies).

Still, I can see how that statement is true. Columbus died, after suffering a disabling illness for years which left him drained physically and emotionally. He died disgraced and out of favor with the royal family whose support formed his most important partnership for his most famous voyages. He died denied perpetual royalties to his newly discovered territory and trade route. Finally Christopher Columbus died before his greatest discovery was itself understood.

disabling illness
Columbus suffered from reactive arthritis or Reiter’s syndrome which caused him to bleed from his eyes, and have sore arthritic joints, making him appear possessed and making it physically difficult for him to get around. His malady was likely caused by hardships which occurred during one of his voyages, eating poorly prepared or rotten food and suffering unclean circumstances. This disease was poorly understood and misdiagnosed in Columbus's time. The medical resources in the 1500s were insufficient to treat the malady and its overt symptoms left him exhausted and with strange characteristics like bleeding from his eyes, both of which were debilitating professionally and personally.

Disgraced
Columbus was recalled from office, first Spanish governor of the Indies, in 1499 by Queen Isabella and King Ferdinand after reports of tyranny conducted by him reached the royal couple. He would never again be appointed to any position by the Spanish royal court.

Columbus had made his fourth and final passage to the Indies in in 1502, three years after being removed as Governor. Columbus was searching for the Strait of Malacca, the passage to the Indian Ocean which he of course never found. This inability to find the path to Asia from his Indies cast a shadow over his discovery of the reported new trade route he believed he had found.

I can see how he would have been perceived a failure. Even though he had accumulated great fame and wealth from his discoveries; he was out of favor, disgraced, and denied the monetary benefits of his discovery and the acknowledgement for those discoveries which history would remember him by.

Short Answer:
Noted by whom? Columbus died in his bed, surrounded by his family and friends, well off due to profits from his discoveries.

Still, I can see how that statement is true. He died in great discomfort from an illness he had contracted on his voyages. He died still under the disgrace of having been recalled from office for misconduct. He had been unable to repair his rapport with King Ferdinand after he had been removed from his governorship. He died with his contract with the Spanish Crown which would secure greater wealth for himself and his heirs unsatisfied and not in force. Perhaps most importantly, He died with his greatest discovery still unrealized even by himself.

When Columbus died in 1506, he did not die as the man who had discovered the new world. Nobody yet understood the scope of Columbus's discovery. In 1506 people including Columbus believed he had found islands off the coast of India. Columbus was famous at the time of his death for discovering a new trade route to India, not the new world.

The Death of Christopher Columbus

Columbus himself never knew that he had discovered the New World, nor did anyone else the time. All he thought he had found was outlying bits of Asia.

After Columbus had been removed as Governor of the Indies in 1499 he had made his fourth and final passage to the new world in search of the Strait of Malacca, the passage to the Indian Ocean which he of coarse never found. Calling his discovery of a new more direct path to the rich trade route to India in Question.

Columbus died, without mending his relationship to the Spanish Crown. Columbus had been trying to petitions to have his 10% franchise restored by the King, but those petitions were not successful.

Answer:
Noted by whom? Columbus died in his bed, surrounded by his family and friends, well off due to profits from his discoveries. ( for more than a decade he received lucrative trade royalties from the Indies).

Still, I can see how that statement is true. Columbus died, after suffering a disabling illness for years which left him drained physically and emotionally. He died disgraced and out of favor with the royal family who's support formed his most important partnership for his most famous voyages. He died denied perpetual royalties to his newly discovered territory and trade route. Finally Christopher Columbus died before his greatest discovery was itself understood.

disabling illness
Columbus suffered from reactive arthritis or Reiter’s syndrome which caused him to bleed from his eyes, and have soar arthritic joints; making him appear possessed and physically difficult for him to get around. His malady was likely caused by hardships which occurred during one of his voyages, eating poorly prepared or rotten food and suffering unclean circumstances. This disease was poorly understood and misdiagnosed in Columbus's time. His medical resources in 1500's were insufficient to treat the malady and it overt symptoms left him exhausted and with strange characteristics like bleeding from his eyes both of which were debilitating professionally and personally.

Disgraced
Columbus was recalled from office, first Spanish governor of the Indies in 1499 by Queen Isabella and King Ferdinand after reports of tyranny conducted by him reached the royal couple. He would never again be appointed to position by the Spanish royal court.

Denied Perpetual Royalties
This action, of being recalled, nullified the contract Columbus had with Spanish Crown "Capitulations of Santa Fe", which had guaranteed him and his heirs 10% of all profit taken from the new world.

This combination of maladies and reported misconduct meant King Ferdinand would not entertain his petitions for a new office, nor was he welcomed at court. ( Isabella died in 1504, two years before Columbus).

Before his greatest discovery was itself understood
When Columbus died in 1506, he did not die as the man who had discovered the new world. Nobody yet understood the scope of Columbus's discovery. In 1506 people including Columbus believed he had found islands off the coast of India. Columbus was famous at the time of his death for discovering a new trade route to India, not the new world.

The Death of Christopher Columbus
Columbus himself never knew that he had discovered the New World, nor did anyone else the time. All he thought he had found was outlying bits of Asia.

Columbus had made his fourth and final passage to the Indies in in 1502, three years after being removed as Governor. Columbus was searching for the Strait of Malacca, the passage to the Indian Ocean which he of coarse never found. This inability to find the path to Asia from his Indies cast a shadow over his discovery of the reported new trade route he believed he had found.

I can see how he would have been perceived a failure. Even though he had accumulated great fame and wealth from his discoveries; he was out of favor, disgraced, and denied his monetary benefits of his discovery and the acknowledgement for those discoveries which history would remember him by.