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Bromodomain and WD repeat-containing protein 1

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(Redirected from BRWD1)
BRWD1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBRWD1, C21orf107, N143, WDR9, DCAF19, bromodomain and WD repeat domain containing 1, WRD9
External IDsOMIM: 617824; MGI: 1890651; HomoloGene: 23130; GeneCards: BRWD1; OMA:BRWD1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001007246
NM_018963
NM_033656

NM_001103179
NM_145125
NM_176928

RefSeq (protein)

NP_001007247
NP_061836
NP_387505

NP_001096649
NP_660107
NP_795902

Location (UCSC)Chr 21: 39.18 – 39.32 MbChr 16: 95.79 – 95.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bromodomain and WD repeat-containing protein 1 (BRWD1) also known as WD repeat-containing protein 9 (WDR9) is a protein that in humans is encoded by the BRWD1 gene.[5]

Function

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This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and 8 WD repeats, and the function of this protein is not known. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates 3 transcript variants diverging at the 3' ends.[5]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185658Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022914Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: BRWD1 bromodomain and WD repeat domain containing 1".
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Further reading

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