Ugur Sahin

📃Scientific paper: Prevalence and risk factors of kidney stone disease in population aged 40–70 years old in Kharameh cohort study: a cross-sectional population-based study in southern Iran Abstract: Background Kidney stone is the major cause of morbidity, and its prevalence is increasing in the world. This study aimed to assess the prevalence and risk factors of kidney stone in the adult population of southern Iran based on the data of the Kharameh Cohort Study. Methods This cross-sectional study was conducted on 10,663 individuals aged 40–70 years old, using the baseline data of Kharamah cohort study, which started in 2014. Among all participants, 2251 individuals had a history of kidney stone. The participants’ demographic characteristics, behavioral habits, and the history of underlying diseases were investigated. The crude and Age Standardized Prevalence Rate of kidney stones was calculated. Also, logistic regression was used to identify the predictors of kidney stone. To check the goodness of fit index of the model, we used the Hosmer–Lemeshow test. All analyses were performed in STATA software. Results The prevalence of kidney stone was estimated 21.11%. Also, the Age Standardized Prevalence Rate in men and women was calculated 24.3% and 18.7%, respectively. The mean age of the participants was 52.15 years. Higher prevalence of kidney stone was seen in women aged 40–50 years (40.47%, p  = 0.0001) and moderate level of social economic status (31.47%, p  = 0.03), men with overweight (44.69%, p  < 0.0001) and those in a very high level of social economic status (35.75%, p  = 0.001). The results of multiple logistic regression showed that the chance of h... Continued on ES/IODE ➡️ https://etcse.fr/J6Kk ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Effects of α5 GABA(A) receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease Abstract: AIMS: GABAergic modulation involved in cognitive processing appears to be substantially changed in Alzheimer's disease (AD). In a widely used 5xFAD model of AD, we aimed to assess if negative and positive allosteric modulators of α5 GABA(A) receptors (NAM and PAM, respectively) would affect social interaction, social, object and spatial memory, and neuroinflammation. METHODS: After 10‐day treatment with PAM, NAM, or solvent, 6‐month‐old transgenic and non‐transgenic 5xFAD mice underwent testing in a behavioral battery. Gene expressions of IL‐1β, IL‐6, TNF‐α, GFAP, and IBA‐1 were determined in hippocampus and prefrontal cortex by qPCR. RESULTS: PAM treatment impaired spatial learning in transgenic females compared to solvent‐treated transgenic females, and social recognition in transgenic and non‐transgenic males. NAM treatment declined social interaction in transgenic and non‐transgenic males, while had beneficial effect on cognitive flexibility in non‐transgenic males compared to solvent‐treated non‐transgenic males. Transgenic animals have not fully displayed cognitive symptoms, but neuroinflammation was confirmed. NAM reduced proinflammatory gene expressions in transgenic females and astrogliosis in transgenic males compared to pathological controls. CONCLUSION: PAM and NAM failed to exert favorable behavioral effects in transgenic animals. Suppression of neuroinflammation obtained with NAM calls for more studies with GABAergic ligands in amyloid beta‐ and/or ta... Continued on ES/IODE ➡️ https://etcse.fr/E0Oy6 ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

🎖Check out the Highly cited #Review "Immunotherapy in Melanoma: Recent Advances and Future Directions" 🧐by Andrew Knight et al. UPMC 🔗Find the full paper here: https://lnkd.in/dYU5YP4d Keywords: melanoma; immunotherapy; immune checkpoint blockade; LAG-3; TLR-9; STING; T-VEC; fecal microbiota transplant; adoptive cell therapy

📃Scientific paper: COVID 19 infection clinical features in pediatric patients in Southwestern Iran: a cross-sectional, multi-center study Abstract: With the SARS-CoV-2 pandemic, the impact of recent coronavirus, especially in children, cannot be ignored. In this study, we evaluated the SARS-CoV-2 infection rates and associated features in children less than 18 years of age in “Fars” and “Kohgiluyeh and Boyer Ahmad”, provinces, Iran. 5943 children who were suspected cases to SARS-CoV-2 infection were enrolled in this study. Demographic and clinical data of SARS-CoV-2 patients were collected from 16 February 2020 to 20 June 2021. Underlying conditions were considered in this study as well. Among 5943 patients suspected COVID 19 cases, 13.51% were confirmed by real-time PCR assay. The female/male ratio was 1:1.3 with a mean age of 5.71 years. 11.2% of confirmed patients were transferred and admitted in Pediatric ICU. COVID 19 was significantly higher in children with malignancy and diabetes rather than those with other underlying diseases. Children of all ages were susceptible to COVID 19, and there is no significant difference between both sexes. Most of the COVID 19 cases were in 10–18 years old group. Among a number of children with different underlying diseases, children with malignancy had the highest rate of SARS-CoV-2 infection, followed by those with diabetes. Continued on ES/IODE ➡️ https://etcse.fr/hYmA ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: COVID 19 infection clinical features in pediatric patients in Southwestern Iran: a cross-sectional, multi-center study Abstract: With the SARS-CoV-2 pandemic, the impact of recent coronavirus, especially in children, cannot be ignored. In this study, we evaluated the SARS-CoV-2 infection rates and associated features in children less than 18 years of age in “Fars” and “Kohgiluyeh and Boyer Ahmad”, provinces, Iran. 5943 children who were suspected cases to SARS-CoV-2 infection were enrolled in this study. Demographic and clinical data of SARS-CoV-2 patients were collected from 16 February 2020 to 20 June 2021. Underlying conditions were considered in this study as well. Among 5943 patients suspected COVID 19 cases, 13.51% were confirmed by real-time PCR assay. The female/male ratio was 1:1.3 with a mean age of 5.71 years. 11.2% of confirmed patients were transferred and admitted in Pediatric ICU. COVID 19 was significantly higher in children with malignancy and diabetes rather than those with other underlying diseases. Children of all ages were susceptible to COVID 19, and there is no significant difference between both sexes. Most of the COVID 19 cases were in 10–18 years old group. Among a number of children with different underlying diseases, children with malignancy had the highest rate of SARS-CoV-2 infection, followed by those with diabetes. Continued on ES/IODE ➡️ https://etcse.fr/hYmA ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: COVID 19 infection clinical features in pediatric patients in Southwestern Iran: a cross-sectional, multi-center study Abstract: With the SARS-CoV-2 pandemic, the impact of recent coronavirus, especially in children, cannot be ignored. In this study, we evaluated the SARS-CoV-2 infection rates and associated features in children less than 18 years of age in “Fars” and “Kohgiluyeh and Boyer Ahmad”, provinces, Iran. 5943 children who were suspected cases to SARS-CoV-2 infection were enrolled in this study. Demographic and clinical data of SARS-CoV-2 patients were collected from 16 February 2020 to 20 June 2021. Underlying conditions were considered in this study as well. Among 5943 patients suspected COVID 19 cases, 13.51% were confirmed by real-time PCR assay. The female/male ratio was 1:1.3 with a mean age of 5.71 years. 11.2% of confirmed patients were transferred and admitted in Pediatric ICU. COVID 19 was significantly higher in children with malignancy and diabetes rather than those with other underlying diseases. Children of all ages were susceptible to COVID 19, and there is no significant difference between both sexes. Most of the COVID 19 cases were in 10–18 years old group. Among a number of children with different underlying diseases, children with malignancy had the highest rate of SARS-CoV-2 infection, followed by those with diabetes. Continued on ES/IODE ➡️ https://etcse.fr/fa6Zi ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: COVID 19 infection clinical features in pediatric patients in Southwestern Iran: a cross-sectional, multi-center study Abstract: With the SARS-CoV-2 pandemic, the impact of recent coronavirus, especially in children, cannot be ignored. In this study, we evaluated the SARS-CoV-2 infection rates and associated features in children less than 18 years of age in “Fars” and “Kohgiluyeh and Boyer Ahmad”, provinces, Iran. 5943 children who were suspected cases to SARS-CoV-2 infection were enrolled in this study. Demographic and clinical data of SARS-CoV-2 patients were collected from 16 February 2020 to 20 June 2021. Underlying conditions were considered in this study as well. Among 5943 patients suspected COVID 19 cases, 13.51% were confirmed by real-time PCR assay. The female/male ratio was 1:1.3 with a mean age of 5.71 years. 11.2% of confirmed patients were transferred and admitted in Pediatric ICU. COVID 19 was significantly higher in children with malignancy and diabetes rather than those with other underlying diseases. Children of all ages were susceptible to COVID 19, and there is no significant difference between both sexes. Most of the COVID 19 cases were in 10–18 years old group. Among a number of children with different underlying diseases, children with malignancy had the highest rate of SARS-CoV-2 infection, followed by those with diabetes. Continued on ES/IODE ➡️ https://etcse.fr/hYmA ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

Functional connectomic profile correlates with effective anterior thalamic stimulation for refractory epilepsy

📃Scientific paper: Role of the nigrosome 1 absence as a biomarker in amyotrophic lateral sclerosis Abstract: Introduction The absence of nigrosome 1 on brain MRI and the hyperechogenicity of substantia nigra (SNh) by transcranial sonography are two useful biomarkers in the diagnosis of parkinsonisms. We aimed to evaluate the absence of nigrosome 1 in amyotrophic lateral sclerosis (ALS) and to address its meaning. Methods 136 ALS patients were recruited, including 16 progressive muscular atrophy (PMA) and 22 primary lateral sclerosis (PLS) patients. The SNh area was measured planimetrically by standard protocols. The nigrosome 1 status was qualitatively assessed by two blind evaluators in susceptibility weight images of 3T MRI. Demographic and clinical data were collected and the C9ORF72 expansion was tested in all patients. Results Nigrosome 1 was absent in 30% of ALS patients (36% of PLS, 29% of classical ALS and 19% of PMA patients). There was no relationship between radiological and clinical laterality, nor between nigrosome 1 and SNh area. Male sex (OR = 3.63 [1.51, 9.38], p  = 0.005) and a higher upper motor neuron (UMN) score (OR = 1.10 [1.02, 1.2], p  = 0.022) were independently associated to nigrosome 1 absence, which also was an independent marker of poor survival (HR = 1.79 [1.3, 2.8], p  = 0.013). Conclusion In ALS patients, the absence of nigrosome 1 is associated with male sex, UMN impairment and shorter survival. This suggests that constitutional factors and the degree of pyramidal involvement are related to the substantia nigra involvement in ALS. Thus, n... Continued on ES/IODE ➡️ https://etcse.fr/qRXg ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #amyotrophiclateralsclerosis #als #charcot

📃Scientific paper: Increased prevalence of nodular thyroid disease in patients with Klinefelter syndrome Abstract: Purpose Thyroid dysfunction in patients with Klinefelter syndrome (KS) remains an unresolved issue. Although low free thyroxine (FT4) levels within the normal range and normal thyroid stimulating hormone (TSH) levels have been reported, there is currently no data on nodular thyroid disease in this population. This study aims to evaluate the results of thyroid ultrasound (US) examinations in KS patients compared with healthy controls. Methods A cohort of 122 KS and 85 age-matched healthy male controls underwent thyroid US screening and thyroid hormone analysis. According to US risk-stratification systems, nodules ≥1 cm were examined by fine needle aspiration (FNA). Results Thyroid US detected nodular thyroid disease in 31% of KS compared to 13% of controls. No statistical differences in the maximum diameter of the largest nodules and in moderate and highly suspicious nodules were found between patients and the control group. Six KS patients and two controls with nodules underwent FNA and were confirmed as cytologically benign. In line with published data, FT4 levels were found significantly near the lower limit of the normal range compared to controls, with no differences in TSH values between the two groups. Hashimoto’s thyroiditis was diagnosed in 9% of patients with KS. Conclusions We observed a significantly higher prevalence of nodular thyroid disease in KS compared to the control group. The increase in nodular thyroid disease is likely linked to low levels o... Continued on ES/IODE ➡️ https://etcse.fr/8eL ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

What Pulmonary Artery Obstruction is and how group IV ph comes into the conversation. Watch the presentation: https://lnkd.in/d6pRtJtB

https://lnkd.in/gWjhQ4Hj     Article title: Frequency and types of chromosomal abnormalities in acute lymphoblastic leukemia patients in Turkey   Author(s): Osman Demirhana*, Nilgün Tanrıverdia and Dilara Süleymanovaa   Journal: Archives of Community Medicine and Public Health   Journal ISSN: 2455-5479   Abstract: Objectives: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children and is usually associated with numerical and structural chromosomal changes. The correlations of specific cytogenetic findings with presenting clinical features indicate the prognostic significance of chromosomal abnormalities (CAs) in patients with ALL.   Design and methods: The aim of this study was to describe the types and frequencies of CAs in the childhood and adult ALL patients. To date, his was the largest study to date in of children with ALL in Turkey, and presented the general cytogenetic characteristics of 260 patients diagnosed as having with ALL in a 17-year period. The cytogenetic analyses were performed in the diagnosis of ALL patients.   Results: The karyotype results were normal in 76,9% of 260 patients. However, CAs were detected in 23.1% of all patients. The male-female ratio was 1,5 and median age at diagnosis was 8.58 years in children. the incidence of abnormal karyotype was higher in males than that of females (the male-female ratio=2,62). The 18.1% of these CAs was structural aberrations, and also numerical aberrations were 5.0%. The Ph chromosome t(9;22) translocation was present in 1,2% of children. CAs in addition to Ph+ was observed in one case. Specifically, deletions are the most common karyotype (5,8%) among the patients, Duplications was present in 6 (2,3%) patients. İnversions were detected in two patients (0,8%). The ratio of fragilities and other CAs was 1,9% and 2,3% of all patients, respectively. Among numerical chromosome abnormalities, 7 patients (2,7%) had aneuploidies and poliploidies. One patient also had microchimeric cells.    #AcuteLymphoblasticLeukemia #ChromosomalAberrations #Addiction #SubstanceAbuse #CommunityBehavioralHealth #Biostatistics #HealthServices #CommunityAcquiredPneumonia #CommunityDwelling #Peertechz #CommunityHealth #CommunityHealthAwareness #CommunityHealthCampaigns #CommunityHealthHazards #CommunityHealthNeeds #CommunityHealthPromotion #CommunityHealthServices #CommunityHealthSurveys #CommunityHealthcare #CommunityIntervention #CommunityMentalHealth #CommunityNursing #CommunityPharmacy #CommunityTreatmentAndManagement #EnvironmentalHealth #PeertechzPublications #Epidemics #Endemics #Epidemiology #GlobalAwareness #HealthEconomics #InsuranceMedicine #OccupationalSafetyAndHealth #PublicHealthDentistry #PublicHealthEmergency #PublicHealthInterventions #PublicHealthSurveillance #PublicPolicy #SanitationAndHealth