Jan Engels

Düsseldorf und Umgebung Kontaktinformationen
2037 Follower:innen 500+ Kontakte

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Experienced Co-Founder with a demonstrated history of working in the medical device…

Aktivitäten

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Berufserfahrung und Ausbildung

  • EIT Health

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Veröffentlichungen

  • 4 ways start-ups can keep raising funds during the COVID pandemic

    World Economic Forum

    Short piece on the World Economic Forum's Agenda about ways start-ups can keep raising funds during the covid pandemic

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  • A lateral flow channel immunoassay combining a particle binding zone geometry with nanoparticle labelling amplification

    Sensors and Actuators B: Chemical

    A lateral flow channel immunoassay is described which combines two strategies for signal enhancement. A packed silicagel microparticle matrix, covalently labelled with capture antibodies, was incorporated into a microchannel, providing a detection surface to sample volume ratio at least 20 times the standard wall modified microfluidic channel format. Strong signal amplification was achieved with non-direct fluorescence labelling. Fluorescein diacetate nanoparticles, synthesized by a simple…

    A lateral flow channel immunoassay is described which combines two strategies for signal enhancement. A packed silicagel microparticle matrix, covalently labelled with capture antibodies, was incorporated into a microchannel, providing a detection surface to sample volume ratio at least 20 times the standard wall modified microfluidic channel format. Strong signal amplification was achieved with non-direct fluorescence labelling. Fluorescein diacetate nanoparticles, synthesized by a simple top-down method, increase the number of fluorophores per antibody binding event, compared with a classical molecular fluorescein label. The fluorescent signal generation mechanism, triggered by the addition of a solution of NaOH:DMSO, was optimised to produce highly fluorescent uranin. The packed channel immunoassay showed a linear relationship between fluorescence intensity and antibody concentration for detection of 0.4–1.67 nM in a model system of rabbit polyclonal antibodies (RbIgG) and goat anti-rabbit polyclonal antibodies (Gt-α RbIgG), potentially enabling this format to achieve semi-quantitative or quantitative measurement of multiple target analytes, where packed silica zones modified with different capture antibodies are incorporated into the same microchannel system.

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  • Aggregation-Induced Emissive Nanoparticles for Fluorescence Signaling in a Low Cost Paper-Based Immunoassay

    Colloids and Surfaces B: Biointerfaces

    Low cost paper based immunoassays are receiving interest due to their fast performance and small amounts of biomolecules needed for developing an immunoassay complex. In this work aggregation-induced emissive (AIE) nanoparticles, obtained from a diastereoisomeric mixture of 1,2-di-(4-hydroxyphenyl)-1,2-diphenylethene (TPEDH) in a one-step top-down method, are characterized through Dynamic Light Scattering (DLS), Scanning Electron Microscopy (SEM), and Zeta potential. By measuring the Zeta…

    Low cost paper based immunoassays are receiving interest due to their fast performance and small amounts of biomolecules needed for developing an immunoassay complex. In this work aggregation-induced emissive (AIE) nanoparticles, obtained from a diastereoisomeric mixture of 1,2-di-(4-hydroxyphenyl)-1,2-diphenylethene (TPEDH) in a one-step top-down method, are characterized through Dynamic Light Scattering (DLS), Scanning Electron Microscopy (SEM), and Zeta potential. By measuring the Zeta potential before and after labeling the nanoparticles with antibodies we demonstrate that the colloidal system is stable in a wide pH-range. The AIE-active nanoparticles are deposited on chitosan and glutaraldehyde modified paper pads overcoming the common aggregation-caused quenching (ACQ) effect. Analyte concentrations from 1000 ng and below are applied in a model immunocomplex using Goat anti-Rabbit IgG and Rabbit IgG. In the range of 7.81 ng to 250 ng, linear trends with a high R2 are observed, which leads to a strong increase of the blue fluorescence from the TPEDH nanoparticles.

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  • Super Nova in the Test Tube: Nanocrystals for Mega-Fluorescence Amplification

    Succidia, Labor & More

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Patente

  • Method for visually ruling out acute diseases using colour-marked proteins

    Angemeldet am EU WO2014121781 A1

    The invention relates to a system for ruling out acute conditions, especially acute myocardial infarctions (AMI) or viral infections, by means of a lateral flow immunoassay which uses the universal signalling colours, as on a traffic light, to show or reliably rule out the presence of a particular acute condition, which is indicated by two different signals/colours.

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Auszeichnungen/Preise

  • Kairos K50 Company

    Kairos Society

    Among 50 international startups selected for the 7th annual Kairos Global Summit which takes place on October 13, 2015 in Hollywood, California. The Global Summit experience comprises of a VIP demo day on the world famous Warner Brothers Studios New York streets backlot, intimate conversations with leading VCs and industry thought-leaders, and an after party that night at the Avalon Hollywood.
    This year a group of over 300 mentors will attend the event, including Tim Draper (Founding…

    Among 50 international startups selected for the 7th annual Kairos Global Summit which takes place on October 13, 2015 in Hollywood, California. The Global Summit experience comprises of a VIP demo day on the world famous Warner Brothers Studios New York streets backlot, intimate conversations with leading VCs and industry thought-leaders, and an after party that night at the Avalon Hollywood.
    This year a group of over 300 mentors will attend the event, including Tim Draper (Founding Partner, Draper Fisher Jurvetson), Josh Elman (Partner, Greylock), and Robyn Ward (Head of New Media Ventures, United Talent Agency). Attendees of the Kairos Global Summit will learn what the next generation is developing and form partnerships to bring their products and services to a global scale.

  • Overseas Research Award

    The Hong Kong University of Science and Technology

    Overseas Research Award for selected PhD students, pursuing a part of their research at an overseas research institute.

  • Rice Business Plan Competition (Houston, Texas, America)

    -

    World Largest and Richest Business Plan Competition.
    Top 9 out of 42 competing teams, received significant business validation from 50+ judges (CEOs, fund managers, healthcare professionals, regulatory experts and VCs etc)

  • TiE International Business Plan competiton

    TiE Hong Kong, TiE India

    Rice Track of the TiE business plan competition
    #1 in Hong Kong (Hong Kong TiE Chapter)
    #1 in Delhi, India (Regional Asia Finals), Asia Rising star Award

  • Google Solve For X HKUST Competition (Hong Kong)

    Google

    Startup technology idea listed under google moonshot ideas under healthcare.

  • Chemistry Best Teaching Assistant

    HKUST

Sprachen

  • German

    Muttersprache oder zweisprachig

  • English

    Verhandlungssicher

Organisationen

  • Global Shaper, Hong Kong Hub

    Outgoing Curator

    –Heute

    Outgoing Curator (2019-2020) Curator (2019-2020) Vice-Curator (2018-2019) The Global Shapers Community is a network of city-based Hubs developed and led by young leaders between 20 and 30 years old who want to develop their leadership potential towards serving society. To that end, Hubs undertake local projects to improve their communities. The Global Shapers Community is one of several multi-stakeholder communities at the World Economic Forum.

  • Kairos Soceity

    Fellow

    –Heute

    The Kairos Society is an international nonprofit organization that seeks to develop entrepreneurs from universities around the world. The stated mission of the Kairos Society is "advancing the world through entrepreneurship and innovation." In pursuit of this mission, the organization seeks to foster and develop innovation- driven entrepreneurship and high-impact enterprise through their international network of entrepreneurs, innovators and leaders.Membership is by invitation only and requires…

    The Kairos Society is an international nonprofit organization that seeks to develop entrepreneurs from universities around the world. The stated mission of the Kairos Society is "advancing the world through entrepreneurship and innovation." In pursuit of this mission, the organization seeks to foster and develop innovation- driven entrepreneurship and high-impact enterprise through their international network of entrepreneurs, innovators and leaders.Membership is by invitation only and requires a formal recommendation from one of the organization's many advisers or partners.

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