Holger Becker

💓 Unveiling Insights into #HeartFailure leveraging cutting-edge #AI-#NLP technology: publication in ESC Heart Failure in the spotlight. 🔍 Through a retrospective study, in collaboration with Heart Center Aalst, we aimed to delve deep into the complexities of heart failure (HF). Using advanced #NLP algorithms, we were able to collect and analyze clinical data from over 1000 patients diagnosed with HFrEF or HFmrEF. 📊 Our findings shed light on the intricate relationship between #comorbidities like type 2 diabetes and chronic kidney disease, and their impact on mortality and HF readmission rates. Additionally, we evaluated patients' eligibility for SGLT2is based on European label criteria. 💡 One of the strengths of our study lies in the analysis of a real-world cohort of HF patients, offering invaluable insights into contemporary clinical practice settings. This approach is particularly crucial as HF management continues to evolve rapidly due to paradigm-shifting trials and updated guidelines. In addition, by bridging the gap between #RealWorldData and clinical trial findings, we aim to facilitate more informed treatment decisions and ultimately improve outcomes for patients with heart failure. #RealWorldEvidence #RWE #Cardiology #HeartFailureAwareness #HeartFailureAwarenessDays

12

1 Kommentar

Today's newsletter is all about #MedicalImaging and #biophotonics, including John Oncea's look at their use in improving dentistry, diagnoses, and space travel. Abrisa Technologies - HEF Photonics writes about how autoclavable coatings can endure rigorous sterilization processes in demanding medical and dental settings, ensuring optimal performance and longevity amidst harsh conditions., while IDEX Health & Science, LLC explains how to overcome the challenges of background signals and noise in surgical environments and how optical filters can maximize detection sensitivity in Fluorescence Guided Surgery imaging. Jos. Schneider Optische Werke GmbH describes imaging technologies that allow physicians to examine and assess a patient's body structures and functions in great detail and Zygo describes some common mistakes in measuring medical optics and how to avoid them. Alluxa, Inc touches on temperature dependence in optical filters, Sensors Unlimited defines SWIR, and Gentec-EO explains how fluctuating laser specifications and environmental factors impact medical applications and explores the advantages of laser output measurement for your organization's efficiency and bottom line. https://lnkd.in/gAbUrCXb

3

About Virtual cohort generation and validation with Wouter Huberts e Sabine Verstraeten from Eindhoven University of Technology. #insilicomedicine #insilicoclinicaltrial #SIMCor #virtualcohort #ai #modelling #simulation #science #healthcare #H2020 

4

With the software module ZEISS Spectral RICS, we are releasing a new solution for understanding molecular dynamics of your living samples. In addition to obtaining structural image information of your sample, unveil how proteins of interest move and interact in relation to their position within the cell. Developed in collaboration with Jelle Hendrix (UHasselt, Belgium), Spectral RICS combines LSM imaging with information about the behavior of proteins in their cellular environment. This integrated approach facilitates the identification of regions exhibiting diverse molecular characteristics. Uniquely, through spectral unmixing, Spectral RICS provides an optimal foundation for investigating protein-protein binding behavior. Learn more about the principle of Spectral RICS, see application examples, and learn about all its features and compatibility: https://lnkd.in/eVwiaPvG #SpectralRICS #moleculardynamics #confocal #lsm #imaging

137

1 Kommentar

This new & fascinating 'IN PRACTICE' paper from Söring GmbH looks at tumour resection near functional white matter & the advantages of continuous mapping using a #LEVICS ultrasonic hand piece combined with #IONM "The resection of intrinsic brain tumors is a common procedure in neurosurgery. When the tumour is located near or within highly functional cerebral regions, electrophysiological mapping and monitoring of these regions becomes crucial to minimize the risk of postoperative neurological deficits". Highlights of the paper include: ✅ Why dynamic continuous mapping is useful ✅ The comparison between "dynamic mapping" and "dynamic continuous mapping ✅ Tips and tricks for the correct application and what needs to be considered Click the graphic below to open. For more details or to place an order in the UK, contact: #DeltaSurgical 01782 637009 Sales@DeltaSurgical.co.uk https://lnkd.in/eQMUUKD9

3

🔬 Cubes in Action! We're thrilled to highlight some of the innovative work our customers are doing with our CUBES!   This time, we're highlighting a study by Velislava Zoteva from the Ghent University Department of Radiology.   Glioblastoma(GB) is the most common primary malignant brain tumor in adults. Theranostics focus on targeting mutations and alterations in molecular pathways associated with GB pathogenesis, with recent emphasis on the promising role of PSMA, which is expressed in the GB neovasculature. In this study, the β-CUBE (PET) was used to evaluate PSMA expression. Heterogenous PSMA expression was confirmed in the peritumoral zone of the GB using immunostaining for PSMA and [68Ga/18F]PSMA PET. These findings indicate the suitability of the F98 GB rat model for further exploring the application of PSMA-based imaging and therapy.   In addition, the β-CUBE (PET) was used to examine the maximum administrable activity of [177Lu]PSMA and the corresponding tumor uptake with kidney dosimetry based on [18F]PSMA PET. In order to avoid nephrotoxicity, the maximum administrable activity of [177Lu]PSMA is 54 MBq, corresponding to a maximum dose of approximately 1.12 Gy, locally delivered to the tumor. However, given histological confirmation of PSMA expression primarily in the peritumoral zone, the tumor dose is expected to be higher in that area. [177Lu]PSMA monotherapy may not result in favorable outcomes, so [177Lu]PSMA needs to be administered as adjuvant therapy. 🔍 Interested in more applications like this? Visit the Knowledge Center on our website to see more of our customers' work in the spotlight. 🔗 Link to the application center can be found in the comments.    #CubesInAction #PreclinicalImaging #PreclinicalResearch

40

1 Kommentar

𝗟𝗶𝗽𝗼𝗖𝗼𝗮𝘁’𝘀 𝗻𝗮𝗻𝗼𝗺𝗲𝘁𝗲𝗿-𝘁𝗵𝗶𝗻 𝗰𝗼𝗮𝘁𝗶𝗻𝗴 𝗺𝗲𝗲𝘁𝘀 𝗺𝗶𝗰𝗿𝗼-𝗿𝗼𝗯𝗼𝘁𝗶𝗰𝘀 🤖 💚 Exiting news! In a recent publication in Nature Communications Engineering, the Surgical Robotics Lab at the University of Twente in collaboration with the University of Waterloo, The German University in Cairo, Radboud University Medical Centre Nijmegen, the Netherlands and LipoCoat present a unique way of using magnetically controlled hemocompatible micro-robots for vascular treatments. In this publication, the untethered magnetic robots effectively demonstrate locomotion in a difficult-to-access target site, navigating through the ex vivo porcine abdominal aorta and reaching the distal end of the renal artery. The usage of hemocompatible materials to manufactur such devices is crucial but also the ability of lowering the potential infection risk in clinical settings! We have previously shown in collaboration with HaemoScan that LipoCoat coated medical devices passed all hemocompatibility tests at levels comparable, if not better, than the negative controls. Additionally, LipoCoat's bio-mimicking coating technology used on the here presented robots caused a protein fouling reduction of 95% and bacteria fouling reduction of over 99 % ! This demeonstrates again the versatile application potential of our technology to tackle several problems which are nowadays more than ever crucial in supporting the safetey and health of patients. Authors: Leendert-Jan W. Lightenberg, Nicole Rabou, Constantinos Goulas, Wytze Duinmeijer, Frank Halfwerk, Jutta Arens, Veronika Magdanz, Roger Lomme, Emily Klein Rot, Colin Nijland, Dorothee Wasserberg, H. Remco Liefers, Pascal Jonkheijm, Arturo Susarrey Arce, Michiel Warlé, Islam S. M. Khalil #publication #robots #microrobotics #coating #healthcare #innovation #infectioncontrol #material #surface

105

2 Kommentare

#invision customizable structured light for optogenetic, lithography and biotechnology applications 🔬 #heliopora #lithography #optogenetic #bioengineering #biotechnology #innovations #lightengine #uvprojector #laboratoryequipment

5

New Adaptive Nozzel 3D printer technology AN3DP can be a game changer.

11

❤️ Philips integrates AI tools into cardiovascular ultrasound platform The AI-based applications are FDA 510(k) cleared and will be integrated into the Dutch company’s EPIQ CVx and Affiniti CVx ultrasound systems. Health technology company Philips has launched its next-generation artificial intelligence (AI)-enabled cardiovascular ultrasound platform. The platform is designed to use AI technology to accelerate cardiac ultrasound analysis and lower the burden on echocardiography labs. The applications are US FDA 510(k) cleared and will be integrated into Philips’ EPIQ CVx and Affiniti CVx ultrasound systems. According to the Amsterdam-based firm, the AI applications advance its cardiovascular imaging and diagnosis solutions. Their integration also automates measurements and speeds up workflows to boost productivity. The applications are designed to identify disorders like coronary artery disease and cardio-oncology issues quickly. Philips global cardiovascular ultrasound vice president and business leader David Handler said: “By harnessing the power of AI into our echocardiography solutions, we empower clinicians with enhanced diagnostic capabilities, to ultimately improve patient care and outcomes in the management of coronary and valvular disease, while enhancing overall efficiency in cardiac practice. “For patients, this means consistent image interpretation which can lead to fewer re-scans, shorter and more effective interventional procedures, and potentially faster recovery times.” Read more online: https://lnkd.in/eTuWChsx 📰 Follow Medical Device Developments to receive the latest medical device news daily and to subscribe to our weekly newsletter #MedicalDeviceDevelopments #medicaldevices #medicalmanufacturing

11

We are proud to share that one of our ventures, MindAffect, has successfully secured €1.1 million in Series A funding to advance its groundbreaking hearing diagnostics technology into the market. Originating from Radboud University, MindAffect is developing an innovative patented brain computer interface (BCI) technology that diagnoses hearing impairments using brain signals. Designed to assist over 1.6 billion people worldwide who face challenges with traditional diagnostic tests, Aurora requires no verbal or physical feedback, making it accessible for infants, young children, and adults with disabilities. The infusion of new capital will be used to fuel the development and upcoming launch of Aurora, which is anticipated for next year. Big congratulations to CEO Jennifer Goodall and the rest of the team for reaching this significant milestone. We look forward to seeing how this technology will continue to impact lives around the globe. Curious to learn more about how MindAffect changes the landscape of hearing diagnostics? Read the full article “Dutch startup tests hearing via brain-computer interface” on The Next Web. You'll find a link in the comments below. #NLC #MindAffect #Impactinvesting #AI #healthtech

50

4 Kommentare

Don't miss out! ✨👋  IonOptix Webinar: Excitation-Contraction Coupling: Simultaneous Measures of Intracellular Calcium & Action Potentials Patrick Schönleitner, PhD and Francisco Altamirano, PhD present their work involving simultaneous measurements of intracellular calcium, membrane voltage, and contractility of cardiomyocytes. Key topics include: - From A to Z: How to perform simultaneous multi-parametric epifluorescence & contractility measurements in primary myocytes & hiPSC-CMs - The Good, The Bad, The Ugly: Opportunities, pitfalls, & limitations of simultaneous membrane potential & calcium measurements - Summarize differences between mouse & human cardiac action potentials - Identify pros & cons of hiPSC- derived cardiomyocytes to study cardiac action potentials & calcium handling Learn more about this webinar by accessing this link: https://lnkd.in/e4tC5APW

3

Ophthalmology Electronic Medical Record (EMR) Software Market – Industry Trends and Forecast to 2029 https://lnkd.in/d-WFDEUF #innovation #management #technology #creativity #entrepreneurship #sustainability #inspiration #insights #outbreak #impact

1

We will soon see a huge wave of successful use of AI to improve patient outcomes, better diagnostics, fewer medical malpractices, and improved processes to lower the cost of quality healthcare for all. #health #aihealth

1

#EvaSKIN and #AEVAHE² scanners by EOTECH measure the size of #pores on the #face (number, volume, depth and area). Please check the below article for more details. https://lnkd.in/ejC2hBEU

23

While traditional fluorescent microscopy provides labelling specificity, biological processes are disrupted by phototoxicity and photobleaching. Phi Optics's instruments enable novel biological insights while protecting sample viability through label-free Quantitative Phase Imaging (QPI). Morphological, dynamic, and volumetric information enabled by QPI has already impacted fields as diverse as neuroscience and microbiology, highlighting label-free microscopy's ability to revolutionize our understanding of life at the cellular level. Read more at : https://ow.ly/KFc950ROXRL Visit Phi Optics for more information about CellVista SLIM and CellVista GLIM. #LabelFreeMicroscopy #Biophotonics #LifeSciences #PhiOptics #QPI #Microscopy #Microbiology

8

#FoundationCourse in April: This is what top-notch #training at Patent™ looks like! 💯 During our courses, dental professionals not only learn how to use #Patent Implants to #prevent #periimplantitis, but also receive training in the Patent™ clinical protocol, which is equally crucial for achieving #longterm treatment #success. One key aspect of this protocol involves the atraumatic insertion of Patent™ Implants using only low to moderate torque in order to #minimize #compression on the surrounding bone and thereby preserve its vitality. Maintaining #bone #vitality is essential for swift and ideal healing, laying the foundation for hard- and soft-tissue health and stability. 🙌 Would you like to learn how to avoid peri-implantitis? Reach out to us at 👉 www.mypatent.com/contact or visit 👉 www.mypatent.com/event #mypatent #patentimplants #dental #implants #implant #dentistry #implantology

11