Novogene

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We are pleased to reconnect with you in the Biweekly Research News Digest. In this week's featured articles, researchers utilize cutting-edge sequencing technologies, such as single-cell transcriptome sequencing and eukaryotic mRNA sequencing, to uncover insights into cardiac function, disease mechanisms, and potential therapies. These findings deepen our understanding of cardiac processes and open new avenues for treating heart conditions.

Xylem, the most plentiful tissue on earth, plays a key role in the lateral growth of plants. It typically features a radial system of ray parenchyma cells and an axial system of fusiform cells. Yet there are different types of xylem cells performing diverse functions and their developmental programs and evolutionary origins have not been well explored. Researchers leveraged single-cell sequencing and studied ray and fusiform cells in stem-differentiating xylem from four different woody angiosperms and determined their developmental lineages. The evo-devo framework developed offers insights into the formation of xylem lineages over a hundred million years. https://lnkd.in/e7hU6eu6

Discover how single-cell sequencing has facilitated advancements in the field of regenerative biology and medicine! In collaboration with Novogene, Professor Qiu Qiang and his esteemed research team explored the cellular and molecular mechanisms underlying the rapid growth and renegeration of deer antlers. Their pioneering study provides crucial insights into deer antler regeneration, offers novel perspectives on mammalian regenerative biology and paves the way for future advancements in regenerative medicine. Eager to learn more? Click here to access an interview of Professor Qiu on the research and on his cooperation with Novogene:https://lnkd.in/eXPzJ2ee

Single-cell sequencing technology has revolutionized agronomic research by allowing gene expression and regulation to be analyzed at the individual cell level. Nonetheless, obtaining high-quality single-cell samples from economically important animals and plants is a challenging task. Click here to learn the best practices for preparing samples from pigs, cattle, goats, and chickens, with a focus on tissues like skin, lungs, and epithelial cells. https://lnkd.in/e9ZW3nmD

Cancer cells modify metabolism to produce metabolites that support tumor growth and alter the tumour microenvironment. Although lysine plays multiple roles as biosynthesis, energy production, and antioxidation, its pathological role in cancer is not well understood. Researchers showed that glioblastoma stem cells (GSCs) reprogrammed lysine catabolism by upregulating SLC7A2 and GCDH and downregulating ECHS1, resulting in the accumulation of intracellular crotonyl-CoA and histone H4 lysine crotonylation. A reduction in histone lysine crotonylation impaired tumor growth. That is, lysine restriction slowed tumor growth. The researchers also specified the mechanism in which the loss of histone lysine crotonylation led to deceleratd tumor growth. These findings helped us gain a better understanding of lysine’s role in tumor growth. https://lnkd.in/eUkwJfXv

Single-cell sequencing offers unique insights into cellular behavior and function, significantly advancing our comprehension of disease mechanisms. With the ability to precisely identify potential therapeutic targets and detect rare genetic mutations, single cell sequencing is transforming the landscape of medical research. Join us in leveraging the capabilities of individual cell analysis to propel innovation and enhance patient outcomes. https://lnkd.in/euKdsBrz

Hematopoietic stem cell transplantation consitutes an effective treatment for many diseases, but our knowledge of how hematopoiesis is resonstituted in transplant patients is limited. Researchers revealed the reconstitution dynamics of human allogeneic hematopoietic stem and progenitor cells (HSPCs) post-transplantation with a resolution at the single-cell level. Rapid changes marked by strong proliferation on the first day were observed in the first 30 days, with notably fewer S100Ahigh immunoregulatory neutrophil progenitors found in recipients developing acute graft-versus-host disease (aGVHD). This study enhances understanding of HSPC regeneration and identifies a potential early marker for aGVHD risk, offering critical insights into hematopoietic stem cell transplantation. https://lnkd.in/eiNSkn7H

Discovering and targeting precancerous cells in healthy tissues is a critical challenge for cancer prevention. While massive stabilization of mutant p53 (mutp53) proteins could potentially help to identify precancerous cells, there is a want of in vivo protein-level mutp53 reporters. Researchers developed two transgenic protein-level mutp53 reporters, p53R172H–Akaluc and p53–mCherry, which accurately replicated mutp53 protein dynamics and function in vivo. These reporters facilitated the identification and tracing of rare precancerous clones in deep tissues across various cancer models, revealing their unique features and vulnerabilities and paving the way for precision cancer prevention. Click here to delve deeper： https://lnkd.in/eEfhkSJT

Novogene has been designated as a “10x Genomics Preferred Service Provider,” a testament to its exceptional capabilities in single-cell and spatial omics services. This accolade was formalized during a signing ceremony at which the new Center of Excellence was also unveiled. Since 2017, Novogene has provided 10x Genomics single-cell and spatial sequencing services, aiding in the publication of over 236 high-impact scientific papers across various research domains such as tumor heterogeneity, stem cell differentiation, and more. Till date, Novogene has processed in excess of 20,000 samples, utilizing an array of systems including 10x Chromium, 10x Visium, Cytassist, and 10x Xenium to cater to diverse research requirements. Moving forward, Novogene remains committed to its core values of Professionalism, Innovation, Integrity, and Partnership, striving to deliver unparalleled gene technology products and services.https://lnkd.in/ggGgwk3B