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Here's how you can communicate and address failures with your team members effectively.
Bruce Lee said, "Don't fear failure...in great attempts it is glorious even to fail." If you have never failed in your life, you have not chosen a goal worthy of challenging you to extend beyond your current abilities. What a miserable life it would be if we only tried what we knew for sure we could already do. Imagine if babies decided they should stay crawling all their lives because they can't handle the failures that come with learning to walk. Anything of true value requires overcoming failures. Failure should not be feared or avoided. Embrace failure as it is the necessary stepping stone to success. It nurtures our determination and guides us closer to victory… if we are open to the lesson. "I never lose. I either win or learn"
Aktivitäten
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View my verified achievement from Amazon Web Services (AWS).
View my verified achievement from Amazon Web Services (AWS).
Beliebt bei Ridouane ACHARGUI, Ph.D.
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🔴 Vous voulez voir le film "2004-2024" dans votre ville et bénéficier d'un espace de discussion avec les participants et l'équipe du film ?…
🔴 Vous voulez voir le film "2004-2024" dans votre ville et bénéficier d'un espace de discussion avec les participants et l'équipe du film ?…
Beliebt bei Ridouane ACHARGUI, Ph.D.
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🔴 Vous n'avez pas pu voir le film au cinéma, ou bien vous avez envie de le voir à nouveau avec vos proches ? N'attendez plus ! Le documentaire…
🔴 Vous n'avez pas pu voir le film au cinéma, ou bien vous avez envie de le voir à nouveau avec vos proches ? N'attendez plus ! Le documentaire…
Beliebt bei Ridouane ACHARGUI, Ph.D.
Berufserfahrung und Ausbildung
Bescheinigungen und Zertifikate
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Behavioral Neuroscience & Change Certification
University of Lausanne - UNIL
Ausgestellt:Zertifikats-ID: N79618415050440
Veröffentlichungen
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Brain Micro-Biopsies for in Vivo Longitudinal Investigation of Compulsion in a Model of Addiction
AchiveU
Repetitive activation of the mesolimbic dopamine system by drugs or optogenetic dopamine neuron self-stimulation can lead to compulsive reinforcement-seeking behaviors. The most addictive substances such as cocaine/amphetamines lead to 10-20% of consumers eventually developing an addiction. However, little is known about individual vulnerability to addiction, mainly because investigations have focused on brain changes after drug exposure due to a lack of technology to study the biological…
Repetitive activation of the mesolimbic dopamine system by drugs or optogenetic dopamine neuron self-stimulation can lead to compulsive reinforcement-seeking behaviors. The most addictive substances such as cocaine/amphetamines lead to 10-20% of consumers eventually developing an addiction. However, little is known about individual vulnerability to addiction, mainly because investigations have focused on brain changes after drug exposure due to a lack of technology to study the biological underpinning of addiction in the same animal before and after its exposure to drugs/addictive protocols. Here we showed that this compulsive reinforcement, a characterizing symptom of addiction, is related to an alteration of the orbitofrontal cortex to Dorsal striatum transmission. Then we developed a methodological pipeline combining brain tissue imprinting and sequencing of that brain tissue. Such a method will allow future investigations aiming at identifying addiction risk factors by correlating the gene expression of each naïve mouse with its own behavior during oDASS.
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Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction
Science
Compulsive drug use despite adverse consequences defines addiction. While mesolimbic dopamine signaling is sufficient to drive compulsion, psychostimulants such as cocaine also boost extracellular serotonin (5-HT) by inhibiting reuptake. We used SERT Met172 knockin (SertKI) mice carrying a transporter that no longer binds cocaine to abolish 5-HT transients during drug self-administration. SertKI mice showed an enhanced transition to compulsion. Conversely, pharmacologically elevating 5-HT…
Compulsive drug use despite adverse consequences defines addiction. While mesolimbic dopamine signaling is sufficient to drive compulsion, psychostimulants such as cocaine also boost extracellular serotonin (5-HT) by inhibiting reuptake. We used SERT Met172 knockin (SertKI) mice carrying a transporter that no longer binds cocaine to abolish 5-HT transients during drug self-administration. SertKI mice showed an enhanced transition to compulsion. Conversely, pharmacologically elevating 5-HT reversed the inherently high rate of compulsion transition with optogenetic dopamine self-stimulation. The bidirectional effect on behavior is explained by presynaptic depression of orbitofrontal cortex–to–dorsal striatum synapses induced by 5-HT via 5-HT1B receptors. Consequently, in projection-specific 5-HT1B receptor knockout mice, the fraction of individuals compulsively self-administering cocaine was elevated.
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Correction: Periaqueductal efferents to dopamine and GABA neurons of the VTA.
PLoS One
Neurons in the periaqueductal gray (PAG) modulate threat responses and nociception. Activity in the ventral tegmental area (VTA) on the other hand can cause reinforcement and aversion. While in many situations these behaviors are related, the anatomical substrate of a crosstalk between the PAG and VTA remains poorly understood. Here we describe the anatomical and electrophysiological organization of the VTA-projecting PAG neurons. Using rabies-based, cell type-specific retrograde tracing, we…
Neurons in the periaqueductal gray (PAG) modulate threat responses and nociception. Activity in the ventral tegmental area (VTA) on the other hand can cause reinforcement and aversion. While in many situations these behaviors are related, the anatomical substrate of a crosstalk between the PAG and VTA remains poorly understood. Here we describe the anatomical and electrophysiological organization of the VTA-projecting PAG neurons. Using rabies-based, cell type-specific retrograde tracing, we observed that PAG to VTA projection neurons are evenly distributed along the rostro-caudal axis of the PAG, but concentrated in its posterior and ventrolateral segments. Optogenetic projection targeting demonstrated that the PAG-to-VTA pathway is predominantly excitatory and targets similar proportions of Ih-expressing VTA DA and GABA neurons. Taken together, these results set the framework for functional analysis of the interplay between PAG and VTA in the regulation of reward and aversion.
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Social transmission of food safety depends on synaptic plasticity in the prefrontal cortex
Science
When an animal is facing unfamiliar food, its odor, together with semiochemicals emanating from a conspecific, can constitute a safety message and authorize intake. The piriform cortex (PiC) codes olfactory information, and the inactivation of neurons in the nucleus accumbens (NAc) can acutely trigger consumption. However, the neural circuit and cellular substrate of transition of olfactory perception into value-based actions remain elusive. We detected enhanced activity after social…
When an animal is facing unfamiliar food, its odor, together with semiochemicals emanating from a conspecific, can constitute a safety message and authorize intake. The piriform cortex (PiC) codes olfactory information, and the inactivation of neurons in the nucleus accumbens (NAc) can acutely trigger consumption. However, the neural circuit and cellular substrate of transition of olfactory perception into value-based actions remain elusive. We detected enhanced activity after social transmission between two mice in neurons of the medial prefrontal cortex (mPFC) that target the NAc and receive projections from the PiC. Exposure to a conspecific potentiated the excitatory postsynaptic currents in NAc projectors, whereas blocking transmission from PiC to mPFC prevented social transmission. Thus, synaptic plasticity in the mPFC is a cellular substrate of social transmission of food safety.
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Hippocampal Subgranular Zone FosB Expression Is Critical for Neurogenesis and Learning.
Neuroscience
Neural proliferation in the dentate gyrus (DG) is closely linked with learning and memory, but the transcriptional programming that drives adult proliferation remains incompletely understood. Our lab previously elucidated the critical role of the transcription factor ΔFosB in the dorsal hippocampus (dHPC) in learning and memory, and the FosB gene has been suggested to play a role in neuronal proliferation. However, the subregion-specific and potentially cell-autonomous role of dHPC ΔFosB in…
Neural proliferation in the dentate gyrus (DG) is closely linked with learning and memory, but the transcriptional programming that drives adult proliferation remains incompletely understood. Our lab previously elucidated the critical role of the transcription factor ΔFosB in the dorsal hippocampus (dHPC) in learning and memory, and the FosB gene has been suggested to play a role in neuronal proliferation. However, the subregion-specific and potentially cell-autonomous role of dHPC ΔFosB in neurogenesis-dependent learning has not been studied. Here, we crossed neurotensin receptor-2 (NtsR2) Cre mice, which express Cre within the subgranular zone (SGZ) of dHPC DG, with floxed FosB mice to show that knockout of ΔFosB in hippocampal SGZ neurons reduces antidepressant-induced neurogenesis and impedes hippocampus-dependent learning in the novel object recognition task. Taken together, these data indicate that FosB gene expression in SGZ is necessary for both hippocampal neurogenesis and memory formation.
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Stochastic synaptic plasticity underlying compulsion in a model of addiction.
Nature
Activation of the mesolimbic dopamine system reinforces goal-directed behaviours. With repetitive stimulation-for example, by chronic drug abuse-the reinforcement may become compulsive and intake continues even in the face of major negative consequences. Here we gave mice the opportunity to optogenetically self-stimulate dopaminergic neurons and observed that only a fraction of mice persevered if they had to endure an electric shock. Compulsive lever pressing was associated with an activity…
Activation of the mesolimbic dopamine system reinforces goal-directed behaviours. With repetitive stimulation-for example, by chronic drug abuse-the reinforcement may become compulsive and intake continues even in the face of major negative consequences. Here we gave mice the opportunity to optogenetically self-stimulate dopaminergic neurons and observed that only a fraction of mice persevered if they had to endure an electric shock. Compulsive lever pressing was associated with an activity peak in the projection terminals from the orbitofrontal cortex (OFC) to the dorsal striatum. Although brief inhibition of OFC neurons temporarily relieved compulsive reinforcement, we found that transmission from the OFC to the striatum was permanently potentiated in persevering mice. To establish causality, we potentiated these synapses in vivo in mice that stopped optogenetic self-stimulation of dopamine neurons because of punishment; this led to compulsive lever pressing, whereas depotentiation in persevering mice had the converse effect. In summary, synaptic potentiation of transmission from the OFC to the dorsal striatum drives compulsive reinforcement, a defining symptom of addiction.
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Periaqueductal efferents to dopamine and GABA neurons of the VTA.
PLoS One
Neurons in the periaqueductal gray (PAG) modulate threat responses and nociception. Activity in the ventral tegmental area (VTA) on the other hand can cause reinforcement and aversion. While in many situations these behaviors are related, the anatomical substrate of a crosstalk between the PAG and VTA remains poorly understood. Here we describe the anatomical and electrophysiological organization of the VTA-projecting PAG neurons. Using rabies-based, cell type-specific retrograde tracing, we…
Neurons in the periaqueductal gray (PAG) modulate threat responses and nociception. Activity in the ventral tegmental area (VTA) on the other hand can cause reinforcement and aversion. While in many situations these behaviors are related, the anatomical substrate of a crosstalk between the PAG and VTA remains poorly understood. Here we describe the anatomical and electrophysiological organization of the VTA-projecting PAG neurons. Using rabies-based, cell type-specific retrograde tracing, we observed that PAG to VTA projection neurons are evenly distributed along the rostro-caudal axis of the PAG, but concentrated in its posterior and ventrolateral segments. Optogenetic projection targeting demonstrated that the PAG-to-VTA pathway is predominantly excitatory and targets similar proportions of Ih-expressing VTA DA and GABA neurons. Taken together, these results set the framework for functional analysis of the interplay between PAG and VTA in the regulation of reward and aversion.
Kurse
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Advanced Valuation & Strategy : M&A, Private Equity – Rotterdam University
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Behavioral Change: from a Neuroscientific perspective
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Behavioral Finance – Duke University
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Corporate Finance - Wharton University of Pennsylvania
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Corporate Strategy – UCL School of Management
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Fear & Learning: Neuroscience tools
EPFL
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Financial Markets – Yale University
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Financing and Investing in Infrastructure – Luigi Bocconi University
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Genetics
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Introduction to Corporate Finance
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Leadership Circle Profile 360° Certification
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Leadership Training
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Managing conflicts
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Negotiation skills
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Neurobiology
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Online Master of Business Administration (iMBA) Program Webinar
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Presentation skills
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Private Equity and Venture Capital – Luigi Bocconi University
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Projekte
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🧠 Exploring the Neuroscience of Leadership 🚀
I am thrilled to announce my participation as a speaker in an exciting conference on the fascinating intersection of neuroscience and effective leadership.
We will explore the intricate workings of the brain and its impact on leadership skills and behaviors. By gaining insights from cutting-edge neuroscience research, we will uncover the underlying mechanisms that drive successful leadership.
Attendees can expect to learn about the neuroscience behind decision-making, emotional…I am thrilled to announce my participation as a speaker in an exciting conference on the fascinating intersection of neuroscience and effective leadership.
We will explore the intricate workings of the brain and its impact on leadership skills and behaviors. By gaining insights from cutting-edge neuroscience research, we will uncover the underlying mechanisms that drive successful leadership.
Attendees can expect to learn about the neuroscience behind decision-making, emotional intelligence, and building high-performing teams. We will delve into topics such as cognitive flexibility, empathy, and effective communication, all backed by scientific evidence.
Moreover, I will provide practical applications of neuroscience principles in leadership development. We will discuss strategies to enhance self-awareness, leverage strengths, and cultivate resilience in the face of challenges.
I am honored to share my knowledge and experiences during this event, alongside esteemed experts in the field. Together, we will explore the potential for personal and professional growth, empowering attendees to become exceptional leaders in their respective domains. I look forward to the discussions!
Join me at this enlightening conference, as we unlock the secrets of the brain and harness the power of neuroscience to elevate our leadership capabilities.
#NeuroscienceOfLeadership #LeadershipDevelopment #BrainScience #EffectiveLeadership #NeuroLeadership #ProfessionalGrowth #Conference #Empowerment #PersonalDevelopment
Reserved for AFP partners. Details at registrations.io@proton.me -
🌟 Conquering Addiction: Empowering Lives through a Transformative Workshop 🙌
I am thrilled to announce the upcoming workshop on "Conquering Addiction" in collaboration with AFG. Together, we aim to empower individuals on their journey towards recovery and a healthier, fulfilling life.
In this transformative workshop, we will delve into the complexities of addiction, exploring its underlying causes, its neurobiology, and the impact it has on individuals and their loved ones. Through a compassionate and supportive environment, we will create a space for open…I am thrilled to announce the upcoming workshop on "Conquering Addiction" in collaboration with AFG. Together, we aim to empower individuals on their journey towards recovery and a healthier, fulfilling life.
In this transformative workshop, we will delve into the complexities of addiction, exploring its underlying causes, its neurobiology, and the impact it has on individuals and their loved ones. Through a compassionate and supportive environment, we will create a space for open dialogue, understanding, and healing.
Participants will gain valuable insights into evidence-based strategies for overcoming addiction. We will explore practical tools and techniques that promote self-awareness, resilience, and long-term recovery. From mindfulness practices to cognitive-behavioral approaches, we will equip attendees with empowering resources to navigate the challenges of addiction.
The workshop will also emphasize the importance of building a strong support network. We will discuss the significance of community, peer support, and professional guidance in the recovery process. By fostering connections and providing resources, we aim to create a network of support that extends beyond the workshop.
I am honored to facilitate this workshop and guide individuals towards a path of healing and transformation.
Join us for this empowering workshop and let's embark on a journey of recovery, growth, and renewed vitality. Book your spot at reservations.io@proton.me. See you there !!
#ConqueringAddiction #RecoveryJourney #Empowerment #WellBeing #SupportNetwork #Workshop #Transformation #Healing -
⚛ AI and Neuroscience : the Battle for Human Minds 🧠
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I recently participated in a thought-provoking conference on "AI and Neuroscience: the Battle for Human Minds".
We explored how advances in AI, cognitive biases research and neurosciences are transforming influence and persuasion at scale. Powerful entities now understand exactly what makes our brains tick - and exploit it for profit or control.
We discussed cognitive "triggers" like reciprocity, authority, social proof that AI could hyper-target to manipulate opinions and behaviors…I recently participated in a thought-provoking conference on "AI and Neuroscience: the Battle for Human Minds".
We explored how advances in AI, cognitive biases research and neurosciences are transforming influence and persuasion at scale. Powerful entities now understand exactly what makes our brains tick - and exploit it for profit or control.
We discussed cognitive "triggers" like reciprocity, authority, social proof that AI could hyper-target to manipulate opinions and behaviors. Neuroscientific approaches like neuromarketing may soon read consumer minds more accurately than people know themselves.
Take home message? As AI becomes an extension of human bias and fallacy rather than reason, we must educate ourselves on cognitive illusions through fields like neuroscience and psychology. Self-awareness of biases may help inoculate against external manipulation. It’s more important than ever to analyze viral messages critically rather than emotionally to preempt exploitation.
An ethical blueprint around transparency, consent and fairness is needed as technologies advance. When you realize how profoundly external forces aim to influence human behavior, the fight for free will and autonomy becomes an inner battle of self-awareness. We each must strive to know our own minds, biases, and decision-making processes more deeply - so we can think for ourselves rather than be passively swayed by invisible manipulations. Gaining insight into how we think is the key safeguard against having our thoughts and actions silently steered by unseen powers without our consent or knowledge.
In an age of hyper-targeted influence, awareness remains our strongest defense of independent thought.
#AI #Neuroscience #CognitiveBiases #Ethics #CriticalThinking #Technology #MindProtection #ResponsibleAI #BrainAndere Mitarbeiter:innen -
🧠 Building Your Mental Health: Insights from Neuroscience 🌟
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Insightful conference! I got the chance to share ideas on the subject of “Building your Mental Health" where we explored strategies to support our brain and well-being.
We talked in depth about the meaning and components of mental health using the latest neuroscience and psychology findings on how our brain functions, specifically the interconnected areas related to mood, stress and cognition. Understanding these neural pathways empowers us with knowledge of what impacts our mental…Insightful conference! I got the chance to share ideas on the subject of “Building your Mental Health" where we explored strategies to support our brain and well-being.
We talked in depth about the meaning and components of mental health using the latest neuroscience and psychology findings on how our brain functions, specifically the interconnected areas related to mood, stress and cognition. Understanding these neural pathways empowers us with knowledge of what impacts our mental state.
I shared important insights on common mental health conditions like anxiety and depression. Social factors that influence our mental health were also discussed. We emphasized the importance of community, sharing emotions, and catching early signs in loved ones.
A great highlight was sharing self-help techniques rooted in neuroscience, like mindfulness meditation, cognitive behavioral therapy, breathing exercises, etc.
The takeaway was that small lifestyle changes, from daily exercise to journaling, can optimize our mental architecture over the long run. Prioritizing self-care proactively fortifies resilience during challenging times.
I am grateful for that opportunity to share knowledge and it was definitely inspiring to see the public participate in the conversation and share their experience.
#MentalHealth #Neuroscience #SelfHelp #WellBeing #Resilience #Mindfulness #MentalDiseases #BrainFunction #Conference -
🧠 Neuroscience: From Neurons to Behavior 🌟
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Great discussion! I participated in a conference on behavioral neuroscience, which provided deep insights into how the brain drives our actions and experiences.
Using research mapping large-scale brain activity, I described the intricate networks between neurons and how they play a role in everything we do.
We discussed how external stimuli shape neural pathways over time. Using research studies, we talked about how behaviors can be modified by environmental factors that alter…Great discussion! I participated in a conference on behavioral neuroscience, which provided deep insights into how the brain drives our actions and experiences.
Using research mapping large-scale brain activity, I described the intricate networks between neurons and how they play a role in everything we do.
We discussed how external stimuli shape neural pathways over time. Using research studies, we talked about how behaviors can be modified by environmental factors that alter our neurobiology.
We also dived into psychopathologies and unpacked some disorders like depression, anxiety and addiction, tracing the biological factors involved. Understanding the neural mechanisms inspiring certain conditions opens doors to new treatment strategies.
A highlight was introducing the public to cutting-edge neuroimaging technologies that provide an unprecedented view inside the "black box" of the mind. The potential for discoveries that could enhance our well-being and performance is immense.
It was fascinating to pull back the curtain on the wetware behind our behaviors. This conference affirmed neuroscience's power to explain human dynamics and how understanding our neural software can optimize both health and potential.
#Neuroscience #Brain #BrainFunction #Health #BrainPlasticity #Collaboration #Innovation #MentalWellbeing #NeurologicalDisorders
Auszeichnungen/Preise
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iGe3 PhD award
The Institute of Genetics and Genomics of Geneva
Ph.D Award for a neuroscience project aiming at developing a method for brain micro-biopsies for in vivo longitudinal investigation of compulsion in a model of addiction.
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University of Geneva Doctoral Fellowship (2016-2022)
UNIGE
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International Mobility Scholarship
Pierre and Marie Curie University (UPMC)
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International Scholarship at Michigan State University (MSU)
Sorbonne
Sprachen
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anglais
Muttersprache oder zweisprachig
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Français
Muttersprache oder zweisprachig
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Espagnol
Fließend
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Arabe
Muttersprache oder zweisprachig
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Rifi
Muttersprache oder zweisprachig
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German
Grundkenntnisse
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Moroccan
Muttersprache oder zweisprachig
Weitere Aktivitäten von Ridouane ACHARGUI, Ph.D.
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🔴 Le collège Avicenne de Nice a gagné son procès contre la ministre de l’Education nationale, Nicole Belloubet, qui souhaitait sa fermeture.
🔴 Le collège Avicenne de Nice a gagné son procès contre la ministre de l’Education nationale, Nicole Belloubet, qui souhaitait sa fermeture.
Beliebt bei Ridouane ACHARGUI, Ph.D.
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🚨 RECHERCHE ALTERNANCE 🚨 Bonjour à tous! Dans le cadre de ma formation en BP (Brevet Professionnel) à l'École de la Librairie qui débute en…
🚨 RECHERCHE ALTERNANCE 🚨 Bonjour à tous! Dans le cadre de ma formation en BP (Brevet Professionnel) à l'École de la Librairie qui débute en…
Beliebt bei Ridouane ACHARGUI, Ph.D.
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J'avais commencé à faire des posts sur Linkedin en Novembre 2021, lorsque je suis rentré de mon expatriation en Iran 🇮🇷 Depuis il y'a du chemin…
J'avais commencé à faire des posts sur Linkedin en Novembre 2021, lorsque je suis rentré de mon expatriation en Iran 🇮🇷 Depuis il y'a du chemin…
Beliebt bei Ridouane ACHARGUI, Ph.D.
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🚀 Looking for speed and reliability? Discover our SFP ports! 🌐 🔄 Versatile Connectivity: SFP ports support both fiber optic and copper…
🚀 Looking for speed and reliability? Discover our SFP ports! 🌐 🔄 Versatile Connectivity: SFP ports support both fiber optic and copper…
Beliebt bei Ridouane ACHARGUI, Ph.D.
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