There is a science-based approach to explaining the dark spot on Uranus. In 2009 (the image and sighting of the spot in question are from 2006) a paper was published titled: "The Dark Spot in the atmosphere of Uranus in 2006: Discovery, description, and dynamical simulations" by H.B. Hammel a, L.A. Sromovsky et. al.. In this work they say that the dark spot is a wind vortex. Quoting the paper: "Regardless of how it is computed, the dark features's zonal velocity is higher than all other velocities measured to date near that latitude". Using computer simulations they are able to predict possible inicial velocities, lifespan of the Vortex, center latitude of the inicial and center latitude when it reached the end of its lifespan. They go further and state that the mere existence of the vortex shows the dynamic and evolving seasonal nature of Uranus's atmosphere.

Paper: https://www.sciencedirect.com/science/article/abs/pii/S0019103509000578

There is a science-based approach to explaining the dark spot on Uranus. In 2009 (the image and sighting of the spot in question are from 2006) a paper was published titled: The Dark Spot in the atmosphere of Uranus in 2006: Discovery, description, and dynamical simulations by H.B. Hammel a, L.A. Sromovsky et. al.. 

In this work they say that the dark spot is a wind vortex. Quoting the paper:

Regardless of how it is computed, the dark features's zonal velocity is higher than all other velocities measured to date near that latitude.

Using computer simulations they are able to predict possible initial velocities, lifespan of the Vortex, center latitude of the initial and center latitude when it reached the end of its lifespan. They go further and state that the mere existence of the vortex shows the dynamic and evolving seasonal nature of Uranus's atmosphere.

So I'd like to know if there is any science-based thinking on the underlying nature of the dark spot on Uranus beyond "it looks dark, like the ones on Neptune".

The abstract explains that the spot has a markedly different spectral character than the one on Neptune:

The dark feature's contrast and extent varied as a function of wavelength, with largest negative contrast occurring at a surprisingly long wavelength when compared with Neptune's dark features: the Uranus feature was detected out to 1.6 μm with a contrast of −0.07, but it was undetectable at 0.467 μm; the Neptune GDS seen by Voyager exhibited its most prominent contrast of −0.12 at 0.48 μm, and was undetectable longward of 0.7 μm. Computational fluid dynamic simulations of the dark feature on Uranus suggest that structure in the zonal wind profile may be a critical factor in the emergence of large sustained

There is a science-based approach to explaining the dark spot on Uranus. In 2009 a paper was published titled: "The Dark Spot in the atmosphere of Uranus in 2006: Discovery, description, and dynamical simulations" by H.B. Hammel a, L.A. Sromovsky et. al.. In this work they say that the dark spot is a wind vortex. Quoting the paper: "Regardless of how it is computed, the dark features's zonal velocity is higher than all other velocities measured to date near that latitude". Using computer simulations they are able to predict possible inicial velocities, lifespan of the Vortex, center latitude of the inicial and center latitude when it reached the end of its lifespan. They go further and state that the mere existence of the vortex shows the dynamic and evolving seasonal nature of Uranus's atmosphere.

Paper: https://www.sciencedirect.com/science/article/abs/pii/S0019103509000578

There is a science-based approach to explaining the dark spot on Uranus. In 2009 (the image and sighting of the spot in question are from 2006) a paper was published titled: "The Dark Spot in the atmosphere of Uranus in 2006: Discovery, description, and dynamical simulations" by H.B. Hammel a, L.A. Sromovsky et. al.. In this work they say that the dark spot is a wind vortex. Quoting the paper: "Regardless of how it is computed, the dark features's zonal velocity is higher than all other velocities measured to date near that latitude". Using computer simulations they are able to predict possible inicial velocities, lifespan of the Vortex, center latitude of the inicial and center latitude when it reached the end of its lifespan. They go further and state that the mere existence of the vortex shows the dynamic and evolving seasonal nature of Uranus's atmosphere.

Paper: https://www.sciencedirect.com/science/article/abs/pii/S0019103509000578