If you're running a 64-bit system, you'll need to create a 32-bit wineWine prefix to mimic older versions of Windows (older than XPWindows XP).
Specify the archarchitecture, and a new path to use for the prefix:
WINEARCH=win32 WINEPREFIX=/path/to/wineprefix winecfg
Configure Wine for the application as needed. There will be more Windows versions listed. Then run:
WINEARCH=win32 WINEPREFIX=/path/to/wineprefix wine virus.exe
Or whatever it is that you need to run.