I recently redirected my C:\Users\Me\Appdata\Roaming folder to my e: drive (where many other folders from my profile have been redirected to for years). This way, if/when I restore an image to c:, my programs' settings can be unaffected, just as my data has been.
My question is, do many malwares infect the C:\Users\Me\Appdata\Roaming folder?