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  • Windows? No. Linux? Maybe, depending on what functionality you can live with.
    – Mokubai
    Commented Jun 28 at 22:31
  • 3
    Are you willing to take it out of the enclosure and put it inside the computer? It either won't be possible, or you'll likely suffer performance issues if you keep it as an external disk (e.g: connected via USB)
    – Attie
    Commented Jun 28 at 22:38
  • Can you, sure. Should you, no - for a variety of reasons. First and foremost, a USB attached drive isn't stable for running an OS - bump the USB cable and the OS can crash, with any data that was currently being written and/or not saved, likely lost or corrupted (Windows can be run from an external drive, it's simply not recommended). Performance will likely be poor(er) when compared to a direct SATA connection, far worse if NVMe. (If doing so is the only option available due to an incompatibility issue, ensure auto-saves for everything are configured for 1 minute.)
    – JW0914
    Commented Jun 29 at 17:14
  • @Mokubai You can run Windows from an external drive, it's simply not recommended since bumping the connector end of the USB cable can cause the OS to crash with a BSOD. You can't install Windows to an external drive though - in order to get Windows onto it, a WIM has to be captured of the OS partition, then applied to the new OS partition on the external drive (it would be recommended to also configure new boot and WinRE partitions on the external drive)
    – JW0914
    Commented Jun 29 at 17:18