Other than what Kache answeredanswered, the trick to prevent further changes/reversions (e.g. if you accidentally attempt to change it from any Windows settings) is to simply DENY "full control" to everyone within the registry.
Dummies Step-by-Step:
- if you are using RegEdit, right click on the "00000010" key on the left navigation tree
- select "Permissions..."
- for each and every "Group or user names" item, check all the boxes under the "Deny" column
- click "OK"
- repeat for the "00000070" key on the left navigation tree
Registry permission changes take effect immediately (try setting or resetting the IME toggle key now - it will not work). As stated in the original answer, for the actual CTRL-SPACE key to be "deactivated" (for the purposes of toggling the IME), you will need to log out and log in again.