Mediterranean dietary components are inversely associated with advanced colorectal polyps: A case-control study
- PMID: 29962818
- PMCID: PMC6021767
- DOI: 10.3748/wjg.v24.i24.2617
Mediterranean dietary components are inversely associated with advanced colorectal polyps: A case-control study
Abstract
Aim: To evaluate the association between the Mediterranean diet (MD) pattern and its components, and advanced colorectal polyps (adenoma and serrated adenoma).
Methods: A case-control study among patients undergoing screening, diagnostic or surveillance colonoscopies during 2010-2015 at the Tel-Aviv Medical Center, Gastroenterology Department. Cases with advanced polyps were defined as: Advanced adenoma [> 10 mm, with features of high grade dysplasia (HGD) or villous histology], advanced serrated adenoma (> 10 mm or with dysplasia) or multiple (≥ 3) non-advanced adenomas or serrated adenomas. Cases of non-advanced adenomas were defined as adenomas < 10 mm, without features of HGD or villous histology. Controls were defined as those without polyps at the current colonoscopy and without a history of colorectal polyps. Data collection included: anthropometrics measured according to a standardized protocol, fasting blood tests performed at the same lab, medical history recorded by a structured interview and dietary intake evaluated by a 116-item food frequency questionnaire. Adherence to the MD components was evaluated according to intake above/below the sample median, for potentially beneficial/detrimental components respectively, as accepted.
Results: We recruited 206 cases with advanced polyps, 192 cases with non-advanced adenoma and 385 controls. The number of adhered MD components was inversely associated with a diagnosis of advanced polyps in a dose-response manner (OR = 0.34, 95%CI: 0.17-0.65; OR = 0.22, 95%CI: 0.11-0.43; and OR = 0.18, 95%CI: 0.07-0.47 for 3-4, 5-7 and 8-10 components, respectively), but not with non-advanced adenomas (OR = 0.54, 95%CI: 0.25-1.13; OR = 0.48, 95%CI: 0.23-0.99; and OR = 0.43, 95%CI: 0.16-1.12 for 3-4, 5-7 and 8-10 components, respectively). Low intake of sugar-sweetened beverages and red meat, as well as high intake of fish, were inversely associated with advanced polyps (OR = 0.56, 95%CI: 0.36-0.87; OR = 0.63, 95%CI: 0.42-0.95; and OR = 0.66, 95%CI: 0.44-0.99, respectively), while only low intake of red meat was inversely associated with non-advanced adenomas (OR = 0.71, 95%CI: 0.49-0.97).
Conclusion: A better adherence to the MD, specifically low intake of sugar-sweetened beverages and red meat as well as high intake of fish, is related to lower odds for advanced polyps.
Keywords: Cancer; Dietary adherence; Fish intake; Red meat intake; Sugar-sweetened beverages.
Conflict of interest statement
Conflict-of-interest statement: None.
Figures
![Figure 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/6021767/bin/WJG-24-2617-g001.gif)
Similar articles
-
Risk Factors for Metachronous Colorectal Cancer or Advanced Adenomas After Endoscopic Resection of High-risk Adenomas.Clin Gastroenterol Hepatol. 2023 Mar;21(3):630-643. doi: 10.1016/j.cgh.2022.12.005. Epub 2022 Dec 20. Clin Gastroenterol Hepatol. 2023. PMID: 36549471 Review.
-
[Distribution characteristics and risk factors of colorectal adenomas].Zhonghua Wei Chang Wai Ke Za Zhi. 2018 Jun 25;21(6):678-684. Zhonghua Wei Chang Wai Ke Za Zhi. 2018. PMID: 29968244 Chinese.
-
Distinct Metabolic Profiles are Associated with Colorectal Adenomas and Serrated Polyps.Obesity (Silver Spring). 2017 Nov;25 Suppl 2:S72-S80. doi: 10.1002/oby.22001. Obesity (Silver Spring). 2017. PMID: 29086511
-
Lifestyle Risk Factors for Serrated Colorectal Polyps: A Systematic Review and Meta-analysis.Gastroenterology. 2017 Jan;152(1):92-104. doi: 10.1053/j.gastro.2016.09.003. Epub 2016 Sep 14. Gastroenterology. 2017. PMID: 27639804 Review.
-
Detection rates of proximal or large serrated polyps in Chinese patients undergoing screening colonoscopy.J Dig Dis. 2012 Sep;13(9):466-71. doi: 10.1111/j.1751-2980.2012.00621.x. J Dig Dis. 2012. PMID: 22908972
Cited by
-
[Research Progress of the Effect of Mediterranean Diet on the Correlation of Lung Cancer].Zhongguo Fei Ai Za Zhi. 2024 Apr 20;27(4):299-305. doi: 10.3779/j.issn.1009-3419.2024.106.09. Zhongguo Fei Ai Za Zhi. 2024. PMID: 38769833 Free PMC article. Review. Chinese.
-
Healthy Lifestyle and Cancer Risk: Modifiable Risk Factors to Prevent Cancer.Nutrients. 2024 Mar 11;16(6):800. doi: 10.3390/nu16060800. Nutrients. 2024. PMID: 38542712 Free PMC article. Review.
-
Distributions and Trends of the Global Burden of Colorectal Cancer Attributable to Dietary Risk Factors over the Past 30 Years.Nutrients. 2023 Dec 30;16(1):132. doi: 10.3390/nu16010132. Nutrients. 2023. PMID: 38201962 Free PMC article.
-
Adherence to Mediterranean diet and its association with multiple colonic polyps of unknown origin: a case-control study.Front Nutr. 2023 Jun 22;10:1186808. doi: 10.3389/fnut.2023.1186808. eCollection 2023. Front Nutr. 2023. PMID: 37426188 Free PMC article.
-
The Diet as a Modulator of Tumor Microenvironment in Colorectal Cancer Patients.Int J Mol Sci. 2023 Apr 15;24(8):7317. doi: 10.3390/ijms24087317. Int J Mol Sci. 2023. PMID: 37108477 Free PMC article. Review.
References
-
- Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017;66:683–691. - PubMed
-
- Eser S, Chang J, Charalambous H, Silverman B, Demetriou A, Yakut C, Nimri O, Pavlou P, Özgür S, Ziogas A, et al. Incidence patterns of colorectal cancers in four countries of the Middle East Cancer Consortium (Cyprus, Jordan, Israel, and İzmir, Turkey) compared with those in the United States Surveillance, Epidemiology, and End Results Program. Turk J Gastroenterol. 2018;29:36–44. - PMC - PubMed
-
- Godos J, Bella F, Torrisi A, Sciacca S, Galvano F, Grosso G. Dietary patterns and risk of colorectal adenoma: a systematic review and meta-analysis of observational studies. J Hum Nutr Diet. 2016;29:757–767. - PubMed
-
- Feng YL, Shu L, Zheng PF, Zhang XY, Si CJ, Yu XL, Gao W, Zhang L. Dietary patterns and colorectal cancer risk: a meta-analysis. Eur J Cancer Prev. 2017;26:201–211. - PubMed
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous