Computed tomographic characteristics of interval and post screen carcinomas in lung cancer screening
- PMID: 25187382
- DOI: 10.1007/s00330-014-3394-4
Computed tomographic characteristics of interval and post screen carcinomas in lung cancer screening
Abstract
Objectives: To analyse computed tomography (CT) findings of interval and post-screen carcinomas in lung cancer screening.
Methods: Consecutive interval and post-screen carcinomas from the Dutch-Belgium lung cancer screening trial were included. The prior screening and the diagnostic chest CT were reviewed by two experienced radiologists in consensus with knowledge of the tumour location on the diagnostic CT.
Results: Sixty-one participants (53 men) were diagnosed with an interval or post-screen carcinoma. Twenty-two (36%) were in retrospect visible on the prior screening CT. Detection error occurred in 20 cancers and interpretation error in two cancers. Errors involved intrabronchial tumour (n = 5), bulla with wall thickening (n = 5), lymphadenopathy (n = 3), pleural effusion (n = 1) and intraparenchymal solid nodules (n = 8). These were missed because of a broad pleural attachment (n = 4), extensive reticulation surrounding a nodule (n = 1) and extensive scarring (n = 1). No definite explanation other than human error was found in two cases. None of the interval or post-screen carcinomas involved a subsolid nodule.
Conclusions: Interval or post-screen carcinomas that were visible in retrospect were mostly due to detection errors of solid nodules, bulla wall thickening or endobronchial lesions. Interval or post-screen carcinomas without explanation other than human errors are rare.
Key points: • 22% of missed carcinomas originally presented as bulla wall thickening on CT. • 22% of missed carcinomas originally presented as endobronchial lesions on CT. • All malignant endobronchial lesions presented as interval carcinomas. • In the NELSON trial subsolid nodules were not a source of missed carcinomas.
Comment in
-
Missed cancers in lung cancer screening--more than meets the eye.Eur Radiol. 2015 Jan;25(1):89-91. doi: 10.1007/s00330-014-3395-3. Epub 2014 Sep 5. Eur Radiol. 2015. PMID: 25189153
Similar articles
-
Inter-observer agreement on the morphology of screening-detected lung cancer: beyond pulmonary nodules and masses.Eur Radiol. 2019 Jul;29(7):3862-3870. doi: 10.1007/s00330-019-06243-3. Epub 2019 May 6. Eur Radiol. 2019. PMID: 31062136
-
Interval lung cancer after a negative CT screening examination: CT findings and outcomes in National Lung Screening Trial participants.Eur Radiol. 2017 Aug;27(8):3249-3256. doi: 10.1007/s00330-016-4705-8. Epub 2017 Jan 3. Eur Radiol. 2017. PMID: 28050695
-
Occurrence and lung cancer probability of new solid nodules at incidence screening with low-dose CT: analysis of data from the randomised, controlled NELSON trial.Lancet Oncol. 2016 Jul;17(7):907-916. doi: 10.1016/S1470-2045(16)30069-9. Epub 2016 Jun 6. Lancet Oncol. 2016. PMID: 27283862 Clinical Trial.
-
Detection of lung cancer through low-dose CT screening (NELSON): a prespecified analysis of screening test performance and interval cancers.Lancet Oncol. 2014 Nov;15(12):1342-50. doi: 10.1016/S1470-2045(14)70387-0. Epub 2014 Oct 1. Lancet Oncol. 2014. PMID: 25282284 Clinical Trial.
-
Retrospective review of lung cancers diagnosed in annual rounds of CT screening.AJR Am J Roentgenol. 2014 Nov;203(5):965-72. doi: 10.2214/AJR.13.12115. Epub 2014 Sep 23. AJR Am J Roentgenol. 2014. PMID: 25247825 Review.
Cited by
-
[Clinical Multi-features Analysis of Cystic Lung Adenocarcinoma and Construction of Invasive Risk Prediction Model].Zhongguo Fei Ai Za Zhi. 2024 Apr 20;27(4):266-275. doi: 10.3779/j.issn.1009-3419.2024.102.14. Zhongguo Fei Ai Za Zhi. 2024. PMID: 38769829 Free PMC article. Chinese.
-
Research in the application of artificial intelligence to lung cancer diagnosis.Front Med (Lausanne). 2024 Jan 30;11:1343485. doi: 10.3389/fmed.2024.1343485. eCollection 2024. Front Med (Lausanne). 2024. PMID: 38352145 Free PMC article. Review.
-
[Progress in Diagnosis and Treatment of Lung Cancer Associated with Cystic Airspaces].Zhongguo Fei Ai Za Zhi. 2023 Oct 20;26(10):774-781. doi: 10.3779/j.issn.1009-3419.2023.101.29. Zhongguo Fei Ai Za Zhi. 2023. PMID: 37989340 Free PMC article. Chinese.
-
Lung Cancer Screening with Low-Dose CT: What We Have Learned in Two Decades of ITALUNG and What Is Yet to Be Addressed.Diagnostics (Basel). 2023 Jun 28;13(13):2197. doi: 10.3390/diagnostics13132197. Diagnostics (Basel). 2023. PMID: 37443590 Free PMC article. Review.
-
Tips and Tricks in Thoracic Radiology for Beginners: A Findings-Based Approach.Tomography. 2023 Jun 14;9(3):1153-1186. doi: 10.3390/tomography9030095. Tomography. 2023. PMID: 37368547 Free PMC article. Review.
References
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical