1.5-T multiparametric MRI using PI-RADS: a region by region analysis to localize the index-tumor of prostate cancer in patients undergoing prostatectomy
- PMID: 24819231
- DOI: 10.1177/0284185114531754
1.5-T multiparametric MRI using PI-RADS: a region by region analysis to localize the index-tumor of prostate cancer in patients undergoing prostatectomy
Abstract
Background: The use of multiparametric magnetic resonance imaging (mpMRI) to detect and localize prostate cancer has increased in recent years. In 2010, the European Society of Urogenital Radiology (ESUR) published guidelines for mpMRI and introduced the Prostate Imaging Reporting and Data System (PI-RADS) for scoring the different parameters.
Purpose: To evaluate the reliability and diagnostic performance of endorectal 1.5-T mpMRI using the PI-RADS to localize the index tumor of prostate cancer in patients undergoing prostatectomy.
Material and methods: This institutional review board IRB-approved, retrospective study included 63 patients (mean age, 60.7 years, median PSA, 8.0). Three observers read mpMRI parameters (T2W, DWI, and DCE) using the PI-RADS, which were compared with the results from whole-mount histopathology that analyzed 27 regions of interest. Inter-observer agreement was calculated as well as sensitivity, specificity, positive predictive value (PPV), and negative predicted value (NPV) by dichotomizing the PI-RADS criteria scores ≥3. A receiver-operating curve (ROC) analysis was performed for the different MR parameters and overall score.
Results: Inter-observer agreement on the overall score was 0.41. The overall score in the peripheral zone achieved sensitivities of 0.41, 0.60, and 0.55 with an NPV of 0.80, 0.84, and 0.83, and in the transitional zone, sensitivities of 0.26, 0.15, and 0.19 with an NPV of 0.92, 0.91, and 0.92 for Observers 1, 2, and 3, respectively. The ROC analysis showed a significantly increased area under the curve (AUC) for the overall score when compared to T2W alone for two of the three observers.
Conclusion: 1.5 T mpMRI using the PI-RADS to localize the index tumor achieved moderate reliability and diagnostic performance.
Keywords: MR diffusion; Urinary; magnetic resonance imaging (MRI); observer performance; prostate.
© The Foundation Acta Radiologica 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
Similar articles
-
Prostate imaging reporting and data system version 2 (PI-RADS v2): a pictorial review.Abdom Radiol (NY). 2017 Jan;42(1):278-289. doi: 10.1007/s00261-016-0871-z. Abdom Radiol (NY). 2017. PMID: 27522352 Free PMC article. Review.
-
Prostate Cancer: The European Society of Urogenital Radiology Prostate Imaging Reporting and Data System Criteria for Predicting Extraprostatic Extension by Using 3-T Multiparametric MR Imaging.Radiology. 2015 Aug;276(2):479-89. doi: 10.1148/radiol.15141412. Epub 2015 Apr 3. Radiology. 2015. PMID: 25848900
-
Use of the Prostate Imaging Reporting and Data System (PI-RADS) for Prostate Cancer Detection with Multiparametric Magnetic Resonance Imaging: A Diagnostic Meta-analysis.Eur Urol. 2015 Jun;67(6):1112-1121. doi: 10.1016/j.eururo.2014.10.033. Epub 2014 Nov 6. Eur Urol. 2015. PMID: 25466942 Review.
-
Evaluation of the prostate imaging reporting and data system for the detection of prostate cancer by the results of targeted biopsy of the prostate.Invest Radiol. 2014 Jun;49(6):411-20. doi: 10.1097/RLI.0000000000000030. Invest Radiol. 2014. PMID: 24598440
-
Histology core-specific evaluation of the European Society of Urogenital Radiology (ESUR) standardised scoring system of multiparametric magnetic resonance imaging (mpMRI) of the prostate.BJU Int. 2013 Dec;112(8):1080-7. doi: 10.1111/bju.12259. Epub 2013 Aug 13. BJU Int. 2013. PMID: 23937255
Cited by
-
Head-to-head comparison of prostate-specific membrane antigen PET and multiparametric MRI in the diagnosis of pretreatment patients with prostate cancer: a meta-analysis.Eur Radiol. 2024 Jun;34(6):4017-4037. doi: 10.1007/s00330-023-10436-2. Epub 2023 Nov 20. Eur Radiol. 2024. PMID: 37981590 Review.
-
Microvascular proliferation is associated with high tumour blood flow by mpMRI and disease progression in primary prostate cancer.Sci Rep. 2023 Oct 20;13(1):17949. doi: 10.1038/s41598-023-45158-4. Sci Rep. 2023. PMID: 37863961 Free PMC article.
-
Assessing Extraprostatic Extension with Multiparametric MRI of the Prostate: Mehralivand Extraprostatic Extension Grade or Extraprostatic Extension Likert Scale?Radiol Imaging Cancer. 2020 Jan 17;2(1):e190071. doi: 10.1148/rycan.2019190071. eCollection 2020 Jan. Radiol Imaging Cancer. 2020. PMID: 33778694 Free PMC article.
-
Uncertainty evaluation of image-based tumour control probability models in radiotherapy of prostate cancer using a visual analytic tool.Phys Imaging Radiat Oncol. 2018 Jan 12;5:5-8. doi: 10.1016/j.phro.2017.12.003. eCollection 2018 Jan. Phys Imaging Radiat Oncol. 2018. PMID: 33458361 Free PMC article.
-
Prostate Imaging Reporting and Data System in prostate cancer staging and planning for radical prostatectomy.Wideochir Inne Tech Maloinwazyjne. 2019 Apr;14(2):262-270. doi: 10.5114/wiitm.2019.83869. Epub 2019 Mar 26. Wideochir Inne Tech Maloinwazyjne. 2019. PMID: 31118993 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous