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Comparative Study
. 2013 Apr 15;13(2):150-4.
doi: 10.1102/1470-7330.2013.0016.

Non-solid lung nodules on low-dose computed tomography: comparison of detection rate between 3 visualization techniques

Ernst Th Scholten  1 , Willem P Th M Mali, Mathias Prokop, Bram van Ginneken, Ron Glandorf, Rob van Klaveren, Matthijs Oudkerk, Pim A de Jong
Affiliations
Comparative Study

Non-solid lung nodules on low-dose computed tomography: comparison of detection rate between 3 visualization techniques

Ernst Th Scholten et al. Cancer Imaging. .

Abstract

Objective: To compare various visualization techniques for the detection of non-solid nodules in low-dose lung cancer screening computed tomography (CT) scans.

Methods: An enriched sample of 216 male lung cancer screening subjects aged 60.4 ± 6.0 years was used. Two blinded independent readers searched for non-solid nodules on 5-mm multiplanar reconstructions, 1-mm slices and 7-mm maximum intensity projections (trial protocol). The reference standard was a consensus diagnosis of all non-solid nodules reported at least once.

Results: Twenty-three individuals (10.6%) had in total 34 non-solid nodules. Interobserver agreement was good (Cohen kappa 0.89-0.95). For both observers, we found no differences between the 3 viewing techniques (P > 0.13).

Conclusion: In low-dose lung cancer screening CT scans, we were unable to find a viewing technique superior to that used in the trial by experienced observers who focused on non-solid nodule detection.

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Figures

Figure 1
Figure 1
Different nodules with 1-mm (i), 7-mm MIP (ii) and 5-mm MPR slices (iii). (a) Small (6 mm) non-solid nodule in the left upper lobe. (b) Larger (11 mm) non-solid nodule in the right upper lobe. (c) Part-solid nodule in the apex of the left lower lobe.
Figure 1
Figure 1
Different nodules with 1-mm (i), 7-mm MIP (ii) and 5-mm MPR slices (iii). (a) Small (6 mm) non-solid nodule in the left upper lobe. (b) Larger (11 mm) non-solid nodule in the right upper lobe. (c) Part-solid nodule in the apex of the left lower lobe.
Figure 1
Figure 1
Different nodules with 1-mm (i), 7-mm MIP (ii) and 5-mm MPR slices (iii). (a) Small (6 mm) non-solid nodule in the left upper lobe. (b) Larger (11 mm) non-solid nodule in the right upper lobe. (c) Part-solid nodule in the apex of the left lower lobe.
Figure 2
Figure 2
Undetected right para-hilar non-solid nodule. (i) 1-mm slice; (ii) 7-mm MIP; nodule missed by one observer; (iii) 5-mm MPR.
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