Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT
- PMID: 22016194
- DOI: 10.1007/s00726-011-1123-8
Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT
Abstract
There has been a growing interest in controlling body weight by increasing dietary levels of leucine recently. By contrast, we have focused on studying the effect of deficiency of branched-chain amino acids (BCAAs) leucine on lipid metabolism. We previously have shown that mice fed a leucine-deficient diet for 7 days exhibit significant changes in lipid metabolism as demonstrated by suppressed lipogenesis in the liver and increased fat mobilization in white adipose tissue, the latter of which was found to be caused by increased lipolysis in WAT and uncoupling protein 1 expression in brown adipose tissue. The goal of our current study is to investigate whether the above effects of leucine deficiency can be generalized to the deficiency of other BCAAs including valine and isoleucine. In our current study, we show that valine or isoleucine deficiency has similar effects on reducing fat mass to leucine deprivation, in a similar manner as those observed during leucine deprivation.
Similar articles
-
Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue.Diabetes. 2010 Jan;59(1):17-25. doi: 10.2337/db09-0929. Epub 2009 Oct 15. Diabetes. 2010. PMID: 19833890 Free PMC article.
-
Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice.Metabolism. 2014 Jun;63(6):841-50. doi: 10.1016/j.metabol.2014.03.006. Epub 2014 Mar 15. Metabolism. 2014. PMID: 24684822
-
TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis.Endocrinology. 2013 Oct;154(10):3577-88. doi: 10.1210/en.2013-1203. Epub 2013 Jul 24. Endocrinology. 2013. PMID: 23885019
-
Zinc-α2-glycoprotein as a marker of fat catabolism in humans.Curr Opin Clin Nutr Metab Care. 2013 May;16(3):267-71. doi: 10.1097/MCO.0b013e32835f816c. Curr Opin Clin Nutr Metab Care. 2013. PMID: 23448999 Review.
-
Brown adipose tissue and thermogenesis.Horm Mol Biol Clin Investig. 2014 Jul;19(1):25-37. doi: 10.1515/hmbci-2014-0022. Horm Mol Biol Clin Investig. 2014. PMID: 25390014 Review.
Cited by
-
A Well-Established Gut Microbiota Enhances the Efficiency of Nutrient Metabolism and Improves the Growth Performance of Trachinotus ovatus.Int J Mol Sci. 2024 May 18;25(10):5525. doi: 10.3390/ijms25105525. Int J Mol Sci. 2024. PMID: 38791564 Free PMC article.
-
Assessing Metabolic Differences Associated with Exposure to Polybrominated Biphenyl and Polychlorinated Biphenyls in the Michigan PBB Registry.Environ Health Perspect. 2023 Oct;131(10):107005. doi: 10.1289/EHP12657. Epub 2023 Oct 10. Environ Health Perspect. 2023. PMID: 37815925 Free PMC article.
-
The Influence of Adipocyte Secretome on Selected Metabolic Fingerprints of Breast Cancer Cell Lines Representing the Four Major Breast Cancer Subtypes.Cells. 2023 Aug 22;12(17):2123. doi: 10.3390/cells12172123. Cells. 2023. PMID: 37681855 Free PMC article.
-
Lysine Deprivation Suppresses Adipogenesis in 3T3-L1 Cells: A Transcriptome Analysis.Int J Mol Sci. 2023 May 28;24(11):9402. doi: 10.3390/ijms24119402. Int J Mol Sci. 2023. PMID: 37298352 Free PMC article.
-
Dietary Isoleucine and Valine: Effects on Lipid Metabolism and Ureagenesis in Pigs Fed with Protein Restricted Diets.Metabolites. 2023 Jan 5;13(1):89. doi: 10.3390/metabo13010089. Metabolites. 2023. PMID: 36677013 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
