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. 2011 Mar;64(3):244-5.
doi: 10.1136/jcp.2010.087676. Epub 2011 Jan 7.

Mature fat cells in the myocardium of patients with tuberous sclerosis complex

Miraude E A P M Adriaensen  1 , Matthijs F M van Oosterhout, Harm H H Feringa, Cornelia M Schaefer-Prokop, Bernard A Zonnenberg, Mathias Prokop
Affiliations

Mature fat cells in the myocardium of patients with tuberous sclerosis complex

Miraude E A P M Adriaensen et al. J Clin Pathol. 2011 Mar.

Abstract

Aim: Routine abdominal CT scans in patients with tuberous sclerosis complex (TSC) showed characteristic fatty foci in the depicted caudal portions of the myocardium. The purpose of this study was to investigate if areas of abnormal myocardium in patients with TSC could also be found in post-mortem specimens.

Methods: A retrospective search of our histopathology database was performed to identify specimens of the heart of patients with TSC. Institutional review board approval was obtained, and patient informed consent was waived. Four specimens were included (mean age, 44 years; range 32-68 years; 2 females).

Results: Two specimens (50%) of the heart showed areas of mature fat cells in the myocardium, without associated inflammation, without associated fibrosis, without entrapped myocardial cells and without a capsule.

Conclusion: Post-mortem specimens of the heart of patients with TSC showed areas of mature fat cells in the myocardium which seem to be unique for TSC.

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