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. 2010;37(3):280-3.

Echocardiographic screening results in patients with tuberous sclerosis complex

Miraude E A P M Adriaensen  1 , Maarten J M Cramer, Madelon E E Brouha, Cornelia M Schaefer-Prokop, Mathias Prokop, Pieter A F M Doevendans, Bernard A Zonnenberg, Harm H H Feringa
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Echocardiographic screening results in patients with tuberous sclerosis complex

Miraude E A P M Adriaensen et al. Tex Heart Inst J. 2010.

Abstract

We sought to examine the frequency of abnormal echocardiographic findings in patients with tuberous sclerosis complex. In a retrospective cohort study, we included all patients with known tuberous sclerosis complex who had been sent to our cardiology department for echocardiographic screening from 1995 through August 2003 (n=56). Two research scientists independently reviewed the reports of the echocardiographic screening examinations for abnormal findings. We used descriptive statistics, the Mann-Whitney U test, and the chi(2) test. The mean age of patients included in the study was 35 years (range, 12-73 yr); 23 patients were male. Abnormal findings were seen in 22 patients (39%). The most common abnormal findings were focal areas of increased intramyocardial echogenicity, which were seen in 16 patients (29%). The clinical consequence of this finding is still unknown. We conclude that echocardiographic abnormalities are common in patients with tuberous sclerosis complex.

Keywords: Adolescent; adult; child; echocardiography; hamartoma/complications; heart neoplasms/ultrasonography; rhabdomyoma/ultrasonography; tuberous sclerosis/complications.

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Figures

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Fig. 1 Echocardiogram (4-chamber view) of a 20-year-old woman with tuberous sclerosis complex shows a focal area of increased echogenicity in the interventricular septum (arrow).
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Fig. 2 Echocardiogram (4-chamber view) of a 23-year-old woman with tuberous sclerosis complex shows 2 focal areas of increased echogenicity: 1 in the interventricular septum (left arrow) and 1 in the left ventricular wall (right arrow).
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