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. 2010 Sep;20(9):2067-73.
doi: 10.1007/s00330-010-1786-7. Epub 2010 Apr 21.

Consequences of digital mammography in population-based breast cancer screening: initial changes and long-term impact on referral rates

Adriana M J Bluekens  1 , Nico Karssemeijer, David Beijerinck, Jan J M Deurenberg, Ruben E van Engen, Mireille J M Broeders, Gerard J den Heeten
Affiliations

Consequences of digital mammography in population-based breast cancer screening: initial changes and long-term impact on referral rates

Adriana M J Bluekens et al. Eur Radiol. 2010 Sep.

Abstract

Objectives: To investigate the referral pattern after the transition to full-field digital mammography (FFDM) in a population-based breast cancer screening programme.

Methods: Preceding the nationwide digitalisation of the Dutch screening programme, an FFDM feasibility study was conducted. Detection and referral rates for FFDM and screen-film mammography (SFM) were compared for first and subsequent screens. Furthermore, radiological characteristics of referrals in digital screening were assessed.

Results: A total of 312,414 screening mammograms were performed (43,913 digital and 268,501 conventional), with 4,473 consecutive referrals (966 following FFDM). Initially the FFDM referral rate peaked, and many false-positive results were noted as a consequence of pseudolesions and increased detection of (benign) microcalcifications. A higher overall referral rate was observed in FFDM screening in both first and subsequent examinations (p < .001), with a significant increase in cancer detection (p = .010).

Conclusion: As a result of initial inexperience with digital screening images implementing FFDM in a population-based breast cancer screening programme may lead to a strong, but temporary increase in referral. Dedicated training in digital screening for radiographers and screening radiologists is therefore recommended. Referral rates decrease and stabilise (learning curve effect) at a higher level than in conventional screening, yet with significantly enhanced cancer detection.

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Figures

Fig. 1
Fig. 1
Time course of referral in a FFDM and b SFM screening for first (○) and subsequent (♦) screening examinations
Fig. 2
Fig. 2
Radiological characteristics of referred lesions in digital mammography (rates per 1,000)
Fig. 3
Fig. 3
Results of a referred masses and b referred microcalcifications (rates per 1,000)
Fig. 4
Fig. 4
Pseudolesion seen with high contrast resolution in FFDM. a Prior screening mammogram (SFM), b screening mammogram followed by referral (FFDM), c mammogram in subsequent clinical assessment (FFDM)
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References

    1. Tabar L, Yen M, Vitak B, Chen H, Smith R, Duffy S. Mammography service screening and mortality in breast cancer patients: 20-year follow-up before and after introduction of screening. Lancet. 2003;361:1405–1410. doi: 10.1016/S0140-6736(03)13143-1. - DOI - PubMed
    1. Otto SJ, Fracheboud J, Looman CW, Broeders MJ, Boer R, Hendriks JH, et al. Initiation of population-based mammography screening in Dutch municipalities and effect on breast-cancer mortality: a systematic review. Lancet. 2003;361:1411–1417. doi: 10.1016/S0140-6736(03)13132-7. - DOI - PubMed
    1. Bick U, Diekmann F. Digital mammography: what do we and what don’t we know? Eur Radiol. 2007;17:1931–1942. doi: 10.1007/s00330-007-0586-1. - DOI - PubMed
    1. Skaane P, Skjennald A. Screen-film mammography versus full-field digital mammography with soft-copy reading: randomised trial in a population-based screening program—Oslo II study. Radiology. 2004;232:197–204. doi: 10.1148/radiol.2321031624. - DOI - PubMed
    1. Rosselli Del Turco M, Mantellini P, Ciatto S, Bonardi R, Martinelli F, Lazzari B, et al. Full-field digital versus screen-film mammography: comparative accuracy in concurrent screening cohorts. AJR. 2007;189:860–866. doi: 10.2214/AJR.07.2303. - DOI - PubMed

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