Staging prostate cancer with dynamic contrast-enhanced endorectal MR imaging prior to radical prostatectomy: experienced versus less experienced readers
- PMID: 16244263
- DOI: 10.1148/radiol.2372041724
Staging prostate cancer with dynamic contrast-enhanced endorectal MR imaging prior to radical prostatectomy: experienced versus less experienced readers
Abstract
Purpose: To prospectively determine the accuracy of experienced and less experienced readers in the interpretation of combined T2-weighted fast spin-echo (SE) magnetic resonance (MR) images and dynamic contrast material-enhanced MR images compared with T2-weighted fast SE alone, with respect to differentiation of stage T2 versus stage T3 prostate carcinoma, with histologic analysis serving as the reference standard.
Materials and methods: Institutional review board approval and informed consent were obtained, and 124 consecutive men (age range, 42-74 years; median age, 63 years) with biopsy-proved prostate cancer underwent MR imaging and were candidates for radical prostatectomy. T2-weighted fast SE MR images and multisection dynamic contrast-enhanced MR images with a 2-second time resolution for the whole prostate were obtained. The T2-weighted and fused color-coded parametric dynamic contrast-enhanced MR images with T2-weighted images were evaluated prospectively and scored with regard to local extent by one experienced reader and evaluated retrospectively by two less experienced readers working in consensus by using a five-point scale; images with a score greater than or equal to four were considered indicative of T3 disease. Results were correlated with whole-mount section histopathologic findings, and receiver operating characteristics analysis was performed.
Results: Twenty-five patients were excluded because of positive findings in the lymph nodes (n = 16), preoperative biopsy-proved seminal vesicle invasion (n = 5), and an absent dynamic dataset (n = 4). Ninety-nine patients were included in this study. The overall sensitivity, specificity, and accuracy of MR staging performance in prostate cancer with dynamic contrast-enhanced MR imaging was 69% (24 of 35 patients), 97% (62 of 64 patients), and 87% (86 of 99 patients), respectively, for the experienced reader. This difference was not significant (P = .48) when results were compared with results from the T2-weighted images. Staging performance for the less experienced readers with parametric dynamic contrast-enhanced MR imaging, however, resulted in significant improvement of the area under the receiver operating characteristics curve (A(z)) compared with T2-weighted MR imaging alone (A(z) = .66 and .82, respectively; P = .01).
Conclusion: The use of multisection dynamic contrast-enhanced MR imaging in staging prostate cancer showed significant improvement in staging performance for the less experienced readers but had no benefit for the experienced reader.
Similar articles
-
Multiparametric MRI in detection and staging of prostate cancer.Dan Med J. 2017 Feb;64(2):B5327. Dan Med J. 2017. PMID: 28157066 Review.
-
Seminal vesicle invasion in prostate cancer: evaluation by using multiparametric endorectal MR imaging.Radiology. 2013 Jun;267(3):797-806. doi: 10.1148/radiol.13121319. Epub 2013 Feb 25. Radiology. 2013. PMID: 23440325 Free PMC article.
-
MR imaging of treated prostate cancer.Radiology. 2012 Jan;262(1):26-42. doi: 10.1148/radiol.11101996. Radiology. 2012. PMID: 22190655 Free PMC article. Review.
-
Prostate cancer: accurate determination of extracapsular extension with high-spatial-resolution dynamic contrast-enhanced and T2-weighted MR imaging--initial results.Radiology. 2007 Oct;245(1):176-85. doi: 10.1148/radiol.2451061502. Epub 2007 Aug 23. Radiology. 2007. PMID: 17717328
-
Prostate cancer: local staging at 3-T endorectal MR imaging--early experience.Radiology. 2006 Jan;238(1):184-91. doi: 10.1148/radiol.2381041832. Epub 2005 Nov 22. Radiology. 2006. PMID: 16304091
Cited by
-
MRI assessment of seminal vesicle involvement by prostate cancer using T2 signal intensity and volume.Abdom Radiol (NY). 2024 May 11. doi: 10.1007/s00261-024-04349-x. Online ahead of print. Abdom Radiol (NY). 2024. PMID: 38734785
-
Magnetic resonance imaging (MRI) for local staging before salvage radical prostatectomy: a meta-analysis.World J Urol. 2023 May;41(5):1275-1284. doi: 10.1007/s00345-023-04383-2. Epub 2023 Apr 5. World J Urol. 2023. PMID: 37019997 Free PMC article. Review.
-
Comparison of Biparametric and Multiparametric Prostate Magnetic Resonance Imaging in Predicting Oncologic Outcomes After Radical Prostatectomy.Medeni Med J. 2022 Dec 28;37(4):313-319. doi: 10.4274/MMJ.galenos.2022.78785. Medeni Med J. 2022. PMID: 36578140 Free PMC article.
-
Promoting the use of the PRECISE score for prostate MRI during active surveillance: results from the ESOR Nicholas Gourtsoyiannis teaching fellowship.Insights Imaging. 2022 Jul 7;13(1):111. doi: 10.1186/s13244-022-01252-1. Insights Imaging. 2022. PMID: 35794256 Free PMC article.
-
Diagnostic Performance of Extraprostatic Extension Grading System for Detection of Extraprostatic Extension in Prostate Cancer: A Diagnostic Systematic Review and Meta-Analysis.Front Oncol. 2022 Jan 25;11:792120. doi: 10.3389/fonc.2021.792120. eCollection 2021. Front Oncol. 2022. PMID: 35145904 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical