Unanswered Questions
200 questions with no upvoted or accepted answers
9
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answer
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Will the sulfur-iodine cycle and Haber Method work at lower pressures and temperatures?
I have a year-long research project next year in my senior year of high school, in which we have to make some product or prototype to solve some issue.
My interest was in the Liquid Fluoride ...
CommunityBot
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8
votes
0
answers
91
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Mechanism of Hypervalent Iodine Phenolic Coupling
I need some help understanding the hypervalent iodine phenolic coupling reaction taking place in this synthesis of morphine, the reaction uses $\ce{PhI(OAc)2}$ as the hypervalent reagent and ...
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7
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289
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How can I solve this synthesis?
I have this task to do:
My solution:
Is that possible? Can you please help me with the steps 2 and 3?
This is what I did, but my teacher told me I should make the diketone (compound no. 5) from ...
- 9,881
7
votes
0
answers
257
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Accurate textbook about synthesis of (organophosphorus) chemical warfare agents
Lately I've been interested in the chemistry of nerve agents due to reading Patrick's Introduction to Medicinal Chemistry in which they were only briefly discussed. I bought the Handbook of Toxicology ...
6
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0
answers
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Cyclic polyynes
Cyclic polyynes have been proposed as theoretical compounds to illustrate the “particle on a ring” model discussed in many quantum chemistry courses. I've looked it up on Wikipedia but there it's not ...
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6
votes
0
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143
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Seeking titanium compound, melting point <1600 °C, decomposes to TiO
The title says it all. I’m new to glass making, and I need a titanium compound that will render me $\ce{TiO}$ through decomposition, and has a melting point under 1600 °C. Hopefully I can get one ...
CommunityBot
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6
votes
1
answer
973
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How did the first amino acids appear on Earth?
Is there proof or a theory that shows that the first amino acid syntheses on Earth were influenced by a change in heat, gravity, radiation, or something similar?
- 10.9k
5
votes
0
answers
46
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Specific question about the total synthesis of B-12
In the process of synthesizing B-12, Woodward & Co. produce an intermediate thioether they refer to as Type I. "Type I because we found early in working with these substances that they were ...
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5
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0
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2k
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Reaction of alkenes with AlCl3/HCl
I stumbled upon an interesting organic chemistry problem:
Previously I thought $\ce{AlCl3}$ would only be used with benzene in acylation and alkylation, but apparently it can also be used in ...
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4
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0
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With two reagents common on Mars, fluorite and CO2, how would I produce carbon tetrafluoride?
The hypothetical terraforming of Mars would require the heating of the atmosphere. A commonly suggested method is the in-situ production of fluorocarbons, powerful greenhouse gases.
For example, ...
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4
votes
0
answers
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Why cool a reaction down when adding reagents if you're only going to reflux subsequently?
I've seen several procedures using thionyl chloride (SOCl2) to make an ester, where the first step is to add the thionyl chloride to the reagent/solvent on ice or subzero temperature, followed ...
- 161
4
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0
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271
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Exchange of Fluorine to Oxygen for Fluorophosphonic acid by silylating agents or other methods?
[Warning, long post!]
Dear all,
I am confronted with a seemingly easy transformation. I want to remove a fluorine atom at a fluor phosphonic acid salt. The usual method to achieve this is the basic ...
CommunityBot
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4
votes
0
answers
114
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Hydrolyse a fluorophosphonic compound / Which protective group strategy can I use for phosphonate esters to access the free acid after a reaction?
I have a synthetic problem in my PhD thesis, in which I synthesize a phosphonate ester.
To be more precise, it is a phosphonofluoridic compound. In my specific case, the fluorine attached to the ...
- 799
4
votes
0
answers
164
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2-Iodoxybenzoic acid oxidation reaction
I was thinking about using 2-Iodoxybenzoic acid to selectively oxidize primary alcohols to aldehydes. I've found papers using various solvents like acetone/water mixture1, 2-methyl-2-propanol2, DMSO ...
- 26.3k
4
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0
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87
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Shi Epoxidation Issues - Any help would be appreciated
As part of my PhD project, I'm currently looking into running a Shi Epoxidation reaction. The first step is to reproduce the current literature on this reaction by using trans-stilbene as my substrate....
